DegronMD - Q9P219(CCDC88C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q505L	TCGA-34-2604	LUSC	TCGA	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.3056
p.Q505L	DO26433	LUSC	ICGC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.3056
p.R807Q	TCGA-AJ-A2QO	UCEC	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation altering degron motif	0.6218
p.R807Q	DO42177	UCEC	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation altering degron motif	0.6218
p.E582K	TCGA-AJ-A3IA	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1389
p.E582K	DO43082	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1389
p.E601D	TCGA-AP-A051	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1111
p.E601D	DO42673	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1111
p.T600M	TCGA-AX-A2HC	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1389
p.T600M	DO233016	GACA	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1389
p.T600M	DO41572	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1389
p.A794V	TCGA-BR-8680	STAD	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.1944
p.A794V	DO47769	STAD	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.1944
p.R796C	TCGA-BR-A4QL	STAD	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.25
p.R796C	DO38723	STAD	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.25
p.E490V	TCGA-CC-A5UD	LIHC	TCGA	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.0556
p.E490V	DO219552	LIHC	ICGC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.0556
p.A798V	TCGA-D1-A17U	UCEC	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.3056
p.A798V	DO41887	UCEC	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.3056
p.M585I	TCGA-D9-A6EC	SKCM	TCGA	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.2222
p.M585I	DO222708	MELA	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.2222
p.M585I	DO50291	SKCM	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.2222
p.L506F	TCGA-DI-A1BU	UCEC	TCGA	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.2778
p.L506F	DO42023	UCEC	ICGC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.2778
p.D802H	TCGA-MI-A75C	LIHC	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation altering degron motif	0.6577
p.D802H	DO49705	LIHC	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation altering degron motif	0.6577
p.G815R	DO228190	LICA	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.1111
p.E491D	DO228937	LICA	ICGC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.0833
p.T598K	DO229019	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1944
p.T600K	DO229036	LICA	ICGC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1389
p.K508N	DO52371	LUSC	ICGC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation substituting flanking lysine	0.3333
p.K501E	DO222395	MELA	ICGC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation altering degron motif	0.7022
p.D802N	DO222749	MELA	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation altering degron motif	0.5821
p.L803V	DO32596	OV	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation altering degron motif	0.6765
p.R483Q	DO229211	THCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.0556
p.A461V	SIDM02067	Colorectal Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.1111
p.R796H	SIDM02013	Colorectal Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.25
p.R796H	ACH-001369	Ovarian Cancer	CCLE	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.25
p.A583V	SIDM00435	Acute Myeloid Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	SIDM00437	Acute Myeloid Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	SIDM00617	Hepatocellular Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	SIDM00308	Chronic Myelogenous Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	SIDM00241	Breast Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	SIDM01617	Endometrial Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	SIDM01368	Gastric Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	SIDM01574	Plasma Cell Myeloma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-000074	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-000255	Gastric Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-000362	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-000369	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-000577	Liver Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-000588	Myeloma	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-000994	Endometrial/Uterine Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-001524	Skin Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	ACH-002179	Breast Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A583V	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.1667
p.A811E	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00845	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00967	Ovarian Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00656	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00846	Cervical Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00875	Breast Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00844	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00032	Bladder Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00793	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00863	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM00641	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811E	SIDM01525	Acute Myeloid Leukemia	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.S507G	SIDM00683	Prostate Carcinoma	GDSC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.25
p.S507G	ACH-000977	lymph node	CCLE	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.25
p.S507G	LNCaP-Clone-FGC	prostate	COSMIC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.25
p.A602P	SIDM01117	Small Cell Lung Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.0833
p.A602P	ACH-002176	Lung Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.0833
p.A602P	NCI-H748	lung	COSMIC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.0833
p.S492G	SIDM00656	Burkitt's Lymphoma	GDSC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.1111
p.S492G	ACH-000944	Lymphoma	CCLE	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.1111
p.S492G	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.1111
p.S580N	SIDM00660	Colorectal Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation blocking phosphorylation signal	0.5278
p.S580N	ACH-000985	Colon/Colorectal Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation blocking phosphorylation signal	0.5278
p.S580N	LS-411N	large intestine	COSMIC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation blocking phosphorylation signal	0.5278
p.V588M	SIDM00889	Cervical Carcinoma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.3056
p.V588M	ACH-001333	Cervical Cancer	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.3056
p.V588M	C-33-A	cervix	COSMIC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.3056
p.L475I	SIDM00596	Endometrial Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.2778
p.L475I	ACH-001517	Endometrial/Uterine Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.2778
p.L475I	HEC-1	endometrium	COSMIC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.2778
p.S463G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.1667
p.S463G	H513	pleura	COSMIC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.1667
p.E459K	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.0556
p.E459K	ACH-000638	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.0556
p.E459K	NCI-H441	lung	COSMIC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.0556
p.A811V	SIDM00217	Colorectal Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.A811V	SNU-1040	large intestine	COSMIC	LRRDLEALR	DEG_APCC_DBOX_1	799:807	Mutation rewiring degron network	0.2222
p.K590R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation altering degron motif	0.7237
p.K590R	SIDM00153	T-Lymphoblastic Leukemia	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation altering degron motif	0.7237
p.K590R	ACH-000964	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation altering degron motif	0.7237
p.K590R	ACH-001127	Leukemia	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation altering degron motif	0.7237
p.K590R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation altering degron motif	0.7237
p.R464H	SIDM00160	Biliary Tract Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.1944
p.R464H	SIDM00248	Gastric Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.1944
p.Q597R	SIDM01473	Plasma Cell Myeloma	GDSC	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.2222
p.Q597R	ACH-000541	Myeloma	CCLE	EKENK	DEG_APCC_KENBOX_2	589:593	Mutation rewiring degron network	0.2222
p.V482I	CCK-81	large intestine	COSMIC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.0833
p.R464C	SK-MEL-2	skin	COSMIC	EKENQ	DEG_APCC_KENBOX_2	469:473	Mutation rewiring degron network	0.1944
p.P492S	GP5d	large intestine	COSMIC	EKENH	DEG_APCC_KENBOX_2	500:504	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC88C

UniProt ID: Q9P219

Entrez ID: 440193

Protein name: Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC88C in