DegronMD

Uniprot ID: Q9P219

Source protein: Protein Daple

Source gene: CCDC88C

Class: DEG_APCC_KENBOX_2

Location: 500:504

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6213

ASA_SCORE: 116.34

COIL: 0.0792

CONS_SCORE: 0.4299

DSS_SCORE: 0.3829

HELIX: 0.9218

FCONS_SCORE: 1.1041

RIG_SCORE: 0.7162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q505L	TCGA-34-2604	LUSC	TCGA	EKENH	DEG_APCC_KENBOX_2	0.3056
p.Q505L	DO26433	LUSC	ICGC	EKENH	DEG_APCC_KENBOX_2	0.3056
p.E490V	TCGA-CC-A5UD	LIHC	TCGA	EKENH	DEG_APCC_KENBOX_2	0.0556
p.E490V	DO219552	LIHC	ICGC	EKENH	DEG_APCC_KENBOX_2	0.0556
p.L506F	TCGA-DI-A1BU	UCEC	TCGA	EKENH	DEG_APCC_KENBOX_2	0.2778
p.L506F	DO42023	UCEC	ICGC	EKENH	DEG_APCC_KENBOX_2	0.2778
p.E491D	DO228937	LICA	ICGC	EKENH	DEG_APCC_KENBOX_2	0.0833
p.K508N	DO52371	LUSC	ICGC	EKENH	DEG_APCC_KENBOX_2	0.3333
p.K501E	DO222395	MELA	ICGC	EKENH	DEG_APCC_KENBOX_2	0.7022
p.S507G	SIDM00683	Prostate Carcinoma	GDSC	EKENH	DEG_APCC_KENBOX_2	0.25
p.S507G	ACH-000977	lymph_node	CCLE	EKENH	DEG_APCC_KENBOX_2	0.25
p.S507G	LNCaP-Clone-FGC	prostate	COSMIC	EKENH	DEG_APCC_KENBOX_2	0.25
p.S492G	SIDM00656	Burkitt's Lymphoma	GDSC	EKENH	DEG_APCC_KENBOX_2	0.1111
p.S492G	ACH-000944	Lymphoma	CCLE	EKENH	DEG_APCC_KENBOX_2	0.1111
p.S492G	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	EKENH	DEG_APCC_KENBOX_2	0.1111
p.P492S	GP5d	large_intestine	COSMIC	EKENH	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	500:504	EKENH	APC,CDC20,FZR1	0.6213	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons