DegronMD

Uniprot ID: Q9P219

Source protein: Protein Daple

Source gene: CCDC88C

Class: DEG_APCC_KENBOX_2

Location: 469:473

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7725

ASA_SCORE: 112.24

COIL: 0.0866

CONS_SCORE: 0.5944

DSS_SCORE: 0.2758

HELIX: 0.914

FCONS_SCORE: 1.249

RIG_SCORE: 0.7763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R483Q	DO229211	THCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.A461V	SIDM02067	Colorectal Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1111
p.L475I	SIDM00596	Endometrial Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.L475I	ACH-001517	Endometrial/Uterine Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.L475I	HEC-1	endometrium	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.S463G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1667
p.S463G	H513	pleura	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.1667
p.E459K	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.E459K	ACH-000638	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.E459K	NCI-H441	lung	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.R464H	SIDM00160	Biliary Tract Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.R464H	SIDM00248	Gastric Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.V482I	CCK-81	large_intestine	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.R464C	SK-MEL-2	skin	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30519	Heme oxygenase 2	DEG_APCC_KENBOX_2	23:27	EKENQ	APC,CDC20,FZR1	0.713	More...
P48681	Nestin	DEG_APCC_KENBOX_2	671:675	EKENQ	APC,CDC20,FZR1	0.5502	More...
P48681	Nestin	DEG_APCC_KENBOX_2	715:719	EKENQ	APC,CDC20,FZR1	0.9987	More...
Q15004	PCNA-associated factor	DEG_APCC_KENBOX_2	77:81	EKENQ	APC,CDC20,FZR1	0.9907	More...
Q16363	Laminin subunit alpha-4	DEG_APCC_KENBOX_2	358:362	EKENQ	APC,CDC20,FZR1	0.7882	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_APCC_KENBOX_2	10:14	EKENQ	APC,CDC20,FZR1	0.9404	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	2540:2544	EKENQ	APC,CDC20,FZR1	0.8952	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	1186:1190	EKENQ	APC,CDC20,FZR1	0.993	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	469:473	EKENQ	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons