DegronMD

Uniprot ID: Q15004

Source protein: PCNA-associated factor

Source gene: PCLAF

Class: DEG_APCC_KENBOX_2

Location: 77:81

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9907

ASA_SCORE: 109.64

COIL: 0.7352

CONS_SCORE: 0.7519

DSS_SCORE: 0.6736

HELIX: 0.2066

FCONS_SCORE: 1.1346

RIG_SCORE: 0.6622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S72Y	SIDM00572	Gastric Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.6389
p.S72Y	NUGC-3	stomach	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.6389
p.S76Y	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.3056
p.S76Y	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.3056
p.R69I	HCC2998	large_intestine	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30519	Heme oxygenase 2	DEG_APCC_KENBOX_2	23:27	EKENQ	APC,CDC20,FZR1	0.713	More...
P48681	Nestin	DEG_APCC_KENBOX_2	671:675	EKENQ	APC,CDC20,FZR1	0.5502	More...
P48681	Nestin	DEG_APCC_KENBOX_2	715:719	EKENQ	APC,CDC20,FZR1	0.9987	More...
Q15004	PCNA-associated factor	DEG_APCC_KENBOX_2	77:81	EKENQ	APC,CDC20,FZR1	0.9907	More...
Q16363	Laminin subunit alpha-4	DEG_APCC_KENBOX_2	358:362	EKENQ	APC,CDC20,FZR1	0.7882	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_APCC_KENBOX_2	10:14	EKENQ	APC,CDC20,FZR1	0.9404	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	2540:2544	EKENQ	APC,CDC20,FZR1	0.8952	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	1186:1190	EKENQ	APC,CDC20,FZR1	0.993	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	469:473	EKENQ	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons