DegronMD - Q16363(LAMA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L349I	TCGA-50-5946	LUAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	358:362	Mutation rewiring degron network	0.0833
p.E1642K	TCGA-5N-A9KM	BLCA	TCGA	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation altering degron motif	0.7022
p.T1634I	TCGA-78-7220	LUAD	TCGA	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.25
p.S1652L	TCGA-86-8073	LUAD	TCGA	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.0556
p.L1726I	TCGA-A5-A1OF	UCEC	TCGA	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation rewiring degron network	0.3056
p.S1627C	TCGA-A8-A06Q	BRCA	TCGA	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.0556
p.E354K	TCGA-AN-A0FY	BRCA	TCGA	EKENQ	DEG_APCC_KENBOX_2	358:362	Mutation rewiring degron network	0.2222
p.P1644L	TCGA-AP-A1DK	UCEC	TCGA	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.2778
p.G1643D	TCGA-AX-A1CE	UCEC	TCGA	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.3056
p.G1643S	TCGA-B0-4698	KIRC	TCGA	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.3056
p.F71L	TCGA-B5-A0JY	UCEC	TCGA	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.F71L	DO43041	UCEC	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.C1727R	TCGA-CU-A72E	BLCA	TCGA	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation rewiring degron network	0.2778
p.V1720F	TCGA-FS-A1ZR	SKCM	TCGA	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation altering degron motif	0.7068
p.D46H	TCGA-LL-A73Y	BRCA	TCGA	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1389
p.D46H	DO50058	BRCA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1389
p.C1720R	DO49734	BLCA	ICGC	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation altering degron motif	0.8301
p.E1635K	DO223517	BLCA	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.2778
p.R54C	DO218693	GACA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.8301
p.E52K	DO233854	GACA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.3056
p.E1647Q	DO15422	HNSC	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.1944
p.G1636S	DO20368	KIRC	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.3056
p.C70F	DO228825	LICA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0833
p.S51R	DO228974	LICA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2778
p.S51R	DO228978	LICA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2778
p.H1725N	DO229025	LICA	ICGC	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation altering degron motif	0.7423
p.T1631N	DO229027	LICA	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.1667
p.T1714K	DO229036	LICA	ICGC	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation rewiring degron network	0.1667
p.T1627I	DO24409	LUAD	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.0556
p.S1645L	DO23624	LUAD	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.25
p.E1647K	DO45482	LUSC	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.1944
p.P69S	DO229446	SKCA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1111
p.P69S	DO41758	UCEC	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1111
p.V1713F	DO37651	SKCM	ICGC	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation rewiring degron network	0.1389
p.R1731I	DO37444	SKCM	ICGC	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation rewiring degron network	0.1667
p.P1637L	DO42033	UCEC	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation altering degron motif	0.7582
p.G1636D	DO42280	UCEC	ICGC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.3056
p.L1719I	DO42568	UCEC	ICGC	VTPKQS	DEG_SCF_FBW7_1	1720:1725	Mutation rewiring degron network	0.3056
p.V55L	ACH-001197	Lymphoma	CCLE	PRVALGRLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.5654
p.V1651L	OVCAR-3	ovary	COSMIC	VTPCFE	DEG_SCF_FBW7_2	1637:1642	Mutation rewiring degron network	0.0833

Kaplan plot for LAMA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAMA4

UniProt ID: Q16363

Entrez ID: 3910

Protein name: Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAMA4 in