DegronMD

Uniprot ID: Q16363

Source protein: Laminin subunit alpha-4

Source gene: LAMA4

Class: DEG_SCF_FBW7_2

Location: 1637:1642

E3 ligase: FBXW7

DEGRON score: 0.9094

ASA_SCORE: 51.5667

COIL: 0.7205

CONS_SCORE: 0.5738

DSS_SCORE: 0.2723

HELIX: 0.0442

FCONS_SCORE: 1.1879

RIG_SCORE: 0.8077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1642K	TCGA-5N-A9KM	BLCA	TCGA	VTPCFE	DEG_SCF_FBW7_2	0.7022
p.T1634I	TCGA-78-7220	LUAD	TCGA	VTPCFE	DEG_SCF_FBW7_2	0.25
p.S1652L	TCGA-86-8073	LUAD	TCGA	VTPCFE	DEG_SCF_FBW7_2	0.0556
p.S1627C	TCGA-A8-A06Q	BRCA	TCGA	VTPCFE	DEG_SCF_FBW7_2	0.0556
p.P1644L	TCGA-AP-A1DK	UCEC	TCGA	VTPCFE	DEG_SCF_FBW7_2	0.2778
p.G1643D	TCGA-AX-A1CE	UCEC	TCGA	VTPCFE	DEG_SCF_FBW7_2	0.3056
p.G1643S	TCGA-B0-4698	KIRC	TCGA	VTPCFE	DEG_SCF_FBW7_2	0.3056
p.E1635K	DO223517	BLCA	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.2778
p.E1647Q	DO15422	HNSC	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.1944
p.G1636S	DO20368	KIRC	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.3056
p.T1631N	DO229027	LICA	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.1667
p.T1627I	DO24409	LUAD	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.0556
p.S1645L	DO23624	LUAD	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.25
p.E1647K	DO45482	LUSC	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.1944
p.P1637L	DO42033	UCEC	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.7582
p.G1636D	DO42280	UCEC	ICGC	VTPCFE	DEG_SCF_FBW7_2	0.3056
p.V1651L	OVCAR-3	ovary	COSMIC	VTPCFE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16363	Laminin subunit alpha-4	DEG_SCF_FBW7_2	1637:1642	VTPCFE	FBXW7	0.9094	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons