DegronMD

Uniprot ID: Q16363

Source protein: Laminin subunit alpha-4

Source gene: LAMA4

Class: DEG_APCC_DBOX_1

Location: 53:61

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.715

ASA_SCORE: 69.4

COIL: 0.8676

CONS_SCORE: 0.2377

DSS_SCORE: 0.5258

HELIX: 0.0221

FCONS_SCORE: 0.9691

RIG_SCORE: 0.7248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F71L	TCGA-B5-A0JY	UCEC	TCGA	PRVALGRLP	DEG_APCC_DBOX_1	0.0556
p.F71L	DO43041	UCEC	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.0556
p.D46H	TCGA-LL-A73Y	BRCA	TCGA	PRVALGRLP	DEG_APCC_DBOX_1	0.1389
p.D46H	DO50058	BRCA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.1389
p.R54C	DO218693	GACA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.8301
p.E52K	DO233854	GACA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.3056
p.C70F	DO228825	LICA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.0833
p.S51R	DO228974	LICA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.2778
p.S51R	DO228978	LICA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.2778
p.P69S	DO229446	SKCA	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.1111
p.P69S	DO41758	UCEC	ICGC	PRVALGRLP	DEG_APCC_DBOX_1	0.1111
p.V55L	ACH-001197	Lymphoma	CCLE	PRVALGRLP	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16363	Laminin subunit alpha-4	DEG_APCC_DBOX_1	53:61	PRVALGRLP	APC,CDC20,FZR1	0.715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons