DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EKENQ
Uniprot ID:
Q16363
Source protein:
Laminin subunit alpha-4
Source gene:
LAMA4
Class:
DEG_APCC_KENBOX_2
Location:
358:362
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7882
ASA_SCORE:
96.4
COIL:
0.1988
CONS_SCORE:
0.4501
DSS_SCORE:
0.4526
HELIX:
0.8012
FCONS_SCORE:
1.3264
RIG_SCORE:
0.7419
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L349I
TCGA-50-5946
LUAD
TCGA
EKENQ
DEG_APCC_KENBOX_2
0.0833
p.E354K
TCGA-AN-A0FY
BRCA
TCGA
EKENQ
DEG_APCC_KENBOX_2
0.2222
Drug responses associated with LAMA4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EKENQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P30519
Heme oxygenase 2
DEG_APCC_KENBOX_2
23:27
EKENQ
APC,CDC20,FZR1
0.713
More...
P48681
Nestin
DEG_APCC_KENBOX_2
671:675
EKENQ
APC,CDC20,FZR1
0.5502
More...
P48681
Nestin
DEG_APCC_KENBOX_2
715:719
EKENQ
APC,CDC20,FZR1
0.9987
More...
Q15004
PCNA-associated factor
DEG_APCC_KENBOX_2
77:81
EKENQ
APC,CDC20,FZR1
0.9907
More...
Q16363
Laminin subunit alpha-4
DEG_APCC_KENBOX_2
358:362
EKENQ
APC,CDC20,FZR1
0.7882
More...
Q5TD94
Radial spoke head protein 4 homolog A
DEG_APCC_KENBOX_2
10:14
EKENQ
APC,CDC20,FZR1
0.9404
More...
Q8N3K9
Cardiomyopathy-associated protein 5
DEG_APCC_KENBOX_2
2540:2544
EKENQ
APC,CDC20,FZR1
0.8952
More...
Q9BXT5
Testis-expressed protein 15
DEG_APCC_KENBOX_2
1186:1190
EKENQ
APC,CDC20,FZR1
0.993
More...
Q9P219
Protein Daple
DEG_APCC_KENBOX_2
469:473
EKENQ
APC,CDC20,FZR1
0.7725
More...