DegronMD

Uniprot ID: Q9BXT5

Source protein: Testis-expressed protein 15

Source gene: TEX15

Class: DEG_APCC_KENBOX_2

Location: 1186:1190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.993

ASA_SCORE: 118.62

COIL: 0.5212

CONS_SCORE: 0.6271

DSS_SCORE: 0.4847

HELIX: 0.4408

FCONS_SCORE: 1.3281

RIG_SCORE: 0.7813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1197Y	TCGA-50-5049	LUAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.1389
p.S1197Y	DO23705	LUAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1389
p.D1181Y	TCGA-64-5815	LUAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.D1181Y	DO23578	LUAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.D1181Y	ACH-000589	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.D1181Y	NCI-H1437	lung	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.E1188K	TCGA-D3-A8GM	SKCM	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.7022
p.E1188K	DO50288	SKCM	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.7022
p.N1189S	TCGA-DI-A1BU	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.7069
p.N1189S	DO42023	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.7069
p.E1188D	TCGA-EE-A2MF	SKCM	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.6758
p.E1188D	DO222491	MELA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.6758
p.E1188D	DO51249	SKCM	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.6758
p.S1200I	TCGA-F5-6814	READ	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.S1200I	DO36556	READ	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.T1193I	TCGA-FI-A2F4	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.25
p.T1193I	DO43434	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.25
p.T1193I	ACH-000994	Endometrial/Uterine Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.25
p.S1198N	TCGA-FU-A3HZ	CESC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.1111
p.S1198N	DO6308	CESC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1111
p.T1193K	DO229015	LICA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.25
p.A1194E	DO229026	LICA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2222
p.S1197C	RD	soft_tissue	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30519	Heme oxygenase 2	DEG_APCC_KENBOX_2	23:27	EKENQ	APC,CDC20,FZR1	0.713	More...
P48681	Nestin	DEG_APCC_KENBOX_2	671:675	EKENQ	APC,CDC20,FZR1	0.5502	More...
P48681	Nestin	DEG_APCC_KENBOX_2	715:719	EKENQ	APC,CDC20,FZR1	0.9987	More...
Q15004	PCNA-associated factor	DEG_APCC_KENBOX_2	77:81	EKENQ	APC,CDC20,FZR1	0.9907	More...
Q16363	Laminin subunit alpha-4	DEG_APCC_KENBOX_2	358:362	EKENQ	APC,CDC20,FZR1	0.7882	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_APCC_KENBOX_2	10:14	EKENQ	APC,CDC20,FZR1	0.9404	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	2540:2544	EKENQ	APC,CDC20,FZR1	0.8952	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	1186:1190	EKENQ	APC,CDC20,FZR1	0.993	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	469:473	EKENQ	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons