DegronMD - P48681(NES)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P721S	TCGA-06-5416	GBM	TCGA	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.2778
p.P721S	DO10880	GBM	ICGC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.2778
p.S680Y	TCGA-06-5416	GBM	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation blocking phosphorylation signal	0.6389
p.S680Y	TCGA-D1-A17Q	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation blocking phosphorylation signal	0.6389
p.S680Y	DO10880	GBM	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation blocking phosphorylation signal	0.6389
p.S680Y	DO41903	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation blocking phosphorylation signal	0.6389
p.E687V	TCGA-50-5066	LUAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.1667
p.E687V	DO25040	LUAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.1667
p.E695D	TCGA-55-A4DF	LUAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation altering degron motif	0.6758
p.E695D	DO45318	LUAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation altering degron motif	0.6758
p.E709Q	TCGA-60-2698	LUSC	TCGA	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1667
p.E709Q	DO26469	LUSC	ICGC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1667
p.L1458Q	TCGA-85-6798	LUSC	TCGA	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.1667
p.L1458Q	DO27295	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.1667
p.G1455V	TCGA-85-8352	LUSC	TCGA	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.25
p.G1455V	DO45540	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.25
p.G1455W	TCGA-85-8352	LUSC	TCGA	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.25
p.G1455W	DO45540	LUSC	ICGC	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.25
p.E706K	TCGA-91-6848	LUAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.0833
p.E706K	TCGA-91-6848	LUAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.0833
p.E706K	DO23846	LUAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.0833
p.E706K	DO23846	LUAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.0833
p.F1606L	TCGA-AA-3977	COAD	TCGA	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.0833
p.F1606L	DO8730	COAD	ICGC	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.0833
p.T585A	TCGA-AJ-A3EL	UCEC	TCGA	EKENK	DEG_APCC_KENBOX_2	590:594	Mutation blocking phosphorylation signal	0.6389
p.T585A	DO41542	UCEC	ICGC	EKENK	DEG_APCC_KENBOX_2	590:594	Mutation blocking phosphorylation signal	0.6389
p.D1621N	TCGA-AP-A051	UCEC	TCGA	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.3056
p.D1621N	DO42673	UCEC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.3056
p.N674H	TCGA-AX-A05Z	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.7423
p.N674H	DO40884	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.7423
p.E662D	TCGA-AX-A05Z	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	TCGA-B5-A0JY	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	TCGA-CA-6717	COAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	DO8264	COAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	DO40884	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	DO43041	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	SIDM00118	Colorectal Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E662D	HCC2998	large intestine	COSMIC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.0833
p.E1610K	TCGA-B5-A11E	UCEC	TCGA	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.1944
p.E1610K	DO41644	UCEC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.1944
p.Q1608H	TCGA-BT-A3PH	BLCA	TCGA	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.1389
p.Q1608H	DO856	BLCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.1389
p.S1462Y	TCGA-DK-A6AW	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0556
p.S1462Y	DO48566	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0556
p.L1449M	TCGA-E8-A2EA	THCA	TCGA	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation altering degron motif	0.5999
p.L1449M	DO38926	THCA	ICGC	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation altering degron motif	0.5999
p.P721L	TCGA-EE-A3AE	SKCM	TCGA	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.2778
p.P721L	DO37802	SKCM	ICGC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.2778
p.R679I	TCGA-EO-A3AY	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.2222
p.R679I	DO43202	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.2222
p.P1439T	TCGA-EO-A3B0	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0833
p.P1439T	DO219773	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	1448:1452	Mutation rewiring degron network	0.0833
p.R1609M	TCGA-G7-6797	KIRP	TCGA	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.1667
p.R1609M	DO20917	KIRP	ICGC	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation rewiring degron network	0.1667
p.R701S	TCGA-GM-A2DB	BRCA	TCGA	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.2222
p.R701S	DO5179	BRCA	ICGC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.2222
p.L700M	TCGA-IB-7651	PAAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.25
p.L700M	DO46657	PAAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.25
p.E595K	TCGA-MP-A4T2	LUAD	TCGA	EKENK	DEG_APCC_KENBOX_2	590:594	Mutation rewiring degron network	0.3056
p.E595K	DO45378	LUAD	ICGC	EKENK	DEG_APCC_KENBOX_2	590:594	Mutation rewiring degron network	0.3056
p.S666L	TCGA-QC-A7B5	SARC	TCGA	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.1944
p.S666L	DO220239	SARC	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.1944
p.E695Q	TCGA-R2-A69V	CESC	TCGA	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation altering degron motif	0.6744
p.E695Q	DO49985	CESC	ICGC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation altering degron motif	0.6744
p.L667F	DO225005	BRCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.2222
p.A688E	DO229009	LICA	ICGC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation rewiring degron network	0.1944
p.L596I	DO232224	PBCA	ICGC	EKENK	DEG_APCC_KENBOX_2	590:594	Mutation rewiring degron network	0.2778
p.L586P	DO229569	PRAD	ICGC	EKENK	DEG_APCC_KENBOX_2	590:594	Mutation rewiring degron network	0.2222
p.E709D	SIDM01179	Other Sarcomas	GDSC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1667
p.E709D	ACH-001702	Sarcoma	CCLE	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1667
p.E709D	VA-ES-BJ	bone	COSMIC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1667
p.S1615F	SIDM00281	Other Solid Cancers	GDSC	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation altering degron motif	0.9093
p.S1615F	ACH-002100	Skin Cancer	CCLE	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation altering degron motif	0.9093
p.S1615F	DJM-1	skin	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	1615:1620	Mutation altering degron motif	0.9093
p.A710S	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1944
p.A710S	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1944
p.A710S	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1944
p.A710S	ACH-000681	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1944
p.A710S	ACH-002337	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1944
p.A710S	A549	lung	COSMIC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.1944
p.E720V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.3056
p.E720V	ACH-000705	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.3056
p.E720V	ACH-001113	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.3056
p.E720V	ACH-002156	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.3056
p.E720V	LC-1-sq	lung	COSMIC	EKENQ	DEG_APCC_KENBOX_2	715:719	Mutation rewiring degron network	0.3056
p.Q697L	SIDM00247	Gastric Carcinoma	GDSC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation altering degron motif	0.6654
p.Q697L	ACH-000356	Gastric Cancer	CCLE	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation altering degron motif	0.6654
p.Q697L	MKN45	stomach	COSMIC	TKENQ	DEG_APCC_KENBOX_2	693:697	Mutation altering degron motif	0.6654

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NES

UniProt ID: P48681

Entrez ID: 10763

Protein name: Nestin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NES in