DegronMD

Uniprot ID: P48681

Source protein: Nestin

Source gene: NES

Class: DEG_Kelch_Keap1_1

Location: 1615:1620

E3 ligase: KEAP1

DEGRON score: 0.9956

ASA_SCORE: 86.15

COIL: 0.902

CONS_SCORE: 0.4386

DSS_SCORE: 0.9077

HELIX: 0.0672

FCONS_SCORE: 1.1972

RIG_SCORE: 0.6478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1606L	TCGA-AA-3977	COAD	TCGA	SWSSGE	DEG_Kelch_Keap1_1	0.0833
p.F1606L	DO8730	COAD	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.0833
p.D1621N	TCGA-AP-A051	UCEC	TCGA	SWSSGE	DEG_Kelch_Keap1_1	0.3056
p.D1621N	DO42673	UCEC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.3056
p.E1610K	TCGA-B5-A11E	UCEC	TCGA	SWSSGE	DEG_Kelch_Keap1_1	0.1944
p.E1610K	DO41644	UCEC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.1944
p.Q1608H	TCGA-BT-A3PH	BLCA	TCGA	SWSSGE	DEG_Kelch_Keap1_1	0.1389
p.Q1608H	DO856	BLCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.1389
p.R1609M	TCGA-G7-6797	KIRP	TCGA	SWSSGE	DEG_Kelch_Keap1_1	0.1667
p.R1609M	DO20917	KIRP	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.1667
p.S1615F	SIDM00281	Other Solid Cancers	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.9093
p.S1615F	ACH-002100	Skin Cancer	CCLE	SWSSGE	DEG_Kelch_Keap1_1	0.9093
p.S1615F	DJM-1	skin	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.9093

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43687	A-kinase anchor protein 7 isoforms alpha and beta	DEG_Kelch_Keap1_1	36:41	SWSSGE	KEAP1	0.9734	More...
P48681	Nestin	DEG_Kelch_Keap1_1	1615:1620	SWSSGE	KEAP1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons