DegronMD - O43687(AKAP7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D44H	TCGA-IR-A3LL	CESC	TCGA	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.25
p.S48G	DO49726	BLCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.1389
p.E42D	DO6308	CESC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.3056
p.E42D	DO37396	READ	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.3056
p.G40D	DO222610	COCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation altering degron motif	0.7198
p.I34T	DO51840	LGG	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.V51L	DO229019	LICA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.0556
p.R39I	DO229019	LICA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation altering degron motif	0.8102
p.R39I	DO43971	UCEC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation altering degron motif	0.8102
p.C27F	DO229028	LICA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.0833
p.E32V	DO27112	LUSC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation substituting flanking lysine	0.3333
p.N36D	DO36009	PBCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation altering degron motif	0.6932
p.K32N	DO47636	SKCM	ICGC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation substituting flanking lysine	0.3333
p.S34F	SIDM00465	Ovarian Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	SIDM00556	Neuroblastoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	SIDM00562	Breast Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	SIDM01653	Non-Cancerous	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	SIDM00207	Glioblastoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	SIDM00531	Pancreatic Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	SIDM00170	Head and Neck Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	KP-N-YN	autonomic ganglia	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	OVMIU	ovary	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	MRK-nu-1	breast	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	HuP-T4	pancreas	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.S34F	KYSE-140	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2778
p.I45T	SIDM00483	Esophageal Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2222
p.I45T	ACH-001654	Esophageal Cancer	CCLE	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2222
p.I45T	SK-GT-4	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.2222
p.A29G	ACH-000229	Non-Cancerous	CCLE	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.1389
p.S33F	OVMIU	ovary	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.25
p.S33F	KYSE-140	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.25
p.S33F	HuP-T4	pancreas	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.25
p.S33F	KP-N-YN	autonomic ganglia	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.25
p.S33F	MRK-nu-1	breast	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.25
p.I44T	SK-GT-4	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	36:41	Mutation rewiring degron network	0.25

Kaplan plot for AKAP7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP7

UniProt ID: O43687

Entrez ID: 9465

Protein name: A-kinase anchor protein 7 isoforms alpha and beta (AKAP-7 isoforms alpha and beta) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoforms alpha/beta) (PRKA7 isoforms alpha/beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP7 in