DegronMD

Uniprot ID: O43687

Source protein: A-kinase anchor protein 7 isoforms alpha and beta

Source gene: AKAP7

Class: DEG_Kelch_Keap1_1

Location: 36:41

E3 ligase: KEAP1

DEGRON score: 0.9734

ASA_SCORE: 68.1

COIL: 0.7753

CONS_SCORE: 0.3135

DSS_SCORE: 0.5751

HELIX: 0.0648

FCONS_SCORE: 0.6742

RIG_SCORE: 0.6117

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D44H	TCGA-IR-A3LL	CESC	TCGA	SWSSGE	DEG_Kelch_Keap1_1	0.25
p.S48G	DO49726	BLCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.1389
p.E42D	DO6308	CESC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.3056
p.E42D	DO37396	READ	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.3056
p.G40D	DO222610	COCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.7198
p.I34T	DO51840	LGG	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.V51L	DO229019	LICA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.0556
p.R39I	DO229019	LICA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.8102
p.R39I	DO43971	UCEC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.8102
p.C27F	DO229028	LICA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.0833
p.E32V	DO27112	LUSC	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.3333
p.N36D	DO36009	PBCA	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.6932
p.K32N	DO47636	SKCM	ICGC	SWSSGE	DEG_Kelch_Keap1_1	0.3333
p.S34F	SIDM00465	Ovarian Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	SIDM00556	Neuroblastoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	SIDM00562	Breast Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	SIDM01653	Non-Cancerous	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	SIDM00207	Glioblastoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	SIDM00531	Pancreatic Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	SIDM00170	Head and Neck Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	KP-N-YN	autonomic_ganglia	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	OVMIU	ovary	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	MRK-nu-1	breast	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	HuP-T4	pancreas	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.S34F	KYSE-140	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.2778
p.I45T	SIDM00483	Esophageal Carcinoma	GDSC	SWSSGE	DEG_Kelch_Keap1_1	0.2222
p.I45T	ACH-001654	Esophageal Cancer	CCLE	SWSSGE	DEG_Kelch_Keap1_1	0.2222
p.I45T	SK-GT-4	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.2222
p.A29G	ACH-000229	Non-Cancerous	CCLE	SWSSGE	DEG_Kelch_Keap1_1	0.1389
p.S33F	OVMIU	ovary	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.25
p.S33F	KYSE-140	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.25
p.S33F	HuP-T4	pancreas	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.25
p.S33F	KP-N-YN	autonomic_ganglia	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.25
p.S33F	MRK-nu-1	breast	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.25
p.I44T	SK-GT-4	oesophagus	COSMIC	SWSSGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43687	A-kinase anchor protein 7 isoforms alpha and beta	DEG_Kelch_Keap1_1	36:41	SWSSGE	KEAP1	0.9734	More...
P48681	Nestin	DEG_Kelch_Keap1_1	1615:1620	SWSSGE	KEAP1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SWSSGE

Degron related mutations and impact score

Drug responses associated with AKAP7 mutations

All proteins holding degron of SWSSGE