DegronMD

Uniprot ID: P48681

Source protein: Nestin

Source gene: NES

Class: DEG_APCC_KENBOX_2

Location: 693:697

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9928

ASA_SCORE: 109.48

COIL: 0.6182

CONS_SCORE: 0.4765

DSS_SCORE: 0.6549

HELIX: 0.3616

FCONS_SCORE: 1.1709

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E687V	TCGA-50-5066	LUAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	0.1667
p.E687V	DO25040	LUAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	0.1667
p.E695D	TCGA-55-A4DF	LUAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	0.6758
p.E695D	DO45318	LUAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	0.6758
p.E706K	TCGA-91-6848	LUAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	0.0833
p.E706K	DO23846	LUAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	0.0833
p.R701S	TCGA-GM-A2DB	BRCA	TCGA	TKENQ	DEG_APCC_KENBOX_2	0.2222
p.R701S	DO5179	BRCA	ICGC	TKENQ	DEG_APCC_KENBOX_2	0.2222
p.L700M	TCGA-IB-7651	PAAD	TCGA	TKENQ	DEG_APCC_KENBOX_2	0.25
p.L700M	DO46657	PAAD	ICGC	TKENQ	DEG_APCC_KENBOX_2	0.25
p.E695Q	TCGA-R2-A69V	CESC	TCGA	TKENQ	DEG_APCC_KENBOX_2	0.6744
p.E695Q	DO49985	CESC	ICGC	TKENQ	DEG_APCC_KENBOX_2	0.6744
p.A688E	DO229009	LICA	ICGC	TKENQ	DEG_APCC_KENBOX_2	0.1944
p.Q697L	SIDM00247	Gastric Carcinoma	GDSC	TKENQ	DEG_APCC_KENBOX_2	0.6654
p.Q697L	ACH-000356	Gastric Cancer	CCLE	TKENQ	DEG_APCC_KENBOX_2	0.6654
p.Q697L	MKN45	stomach	COSMIC	TKENQ	DEG_APCC_KENBOX_2	0.6654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48681	Nestin	DEG_APCC_KENBOX_2	693:697	TKENQ	APC,CDC20,FZR1	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons