DegronMD

Uniprot ID: P48681

Source protein: Nestin

Source gene: NES

Class: DEG_APCC_KENBOX_2

Location: 715:719

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 125.1

COIL: 0.505

CONS_SCORE: 0.4621

DSS_SCORE: 0.5931

HELIX: 0.4948

FCONS_SCORE: 1.233

RIG_SCORE: 0.6653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P721S	TCGA-06-5416	GBM	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.P721S	DO10880	GBM	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.E709Q	TCGA-60-2698	LUSC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.1667
p.E709Q	DO26469	LUSC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1667
p.E706K	TCGA-91-6848	LUAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E706K	DO23846	LUAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.P721L	TCGA-EE-A3AE	SKCM	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.P721L	DO37802	SKCM	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.E709D	SIDM01179	Other Sarcomas	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1667
p.E709D	ACH-001702	Sarcoma	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.1667
p.E709D	VA-ES-BJ	bone	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.1667
p.A710S	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.A710S	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.A710S	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.A710S	ACH-000681	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.A710S	ACH-002337	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.A710S	A549	lung	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.E720V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.3056
p.E720V	ACH-000705	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.3056
p.E720V	ACH-001113	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.3056
p.E720V	ACH-002156	Lung Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.3056
p.E720V	LC-1-sq	lung	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30519	Heme oxygenase 2	DEG_APCC_KENBOX_2	23:27	EKENQ	APC,CDC20,FZR1	0.713	More...
P48681	Nestin	DEG_APCC_KENBOX_2	671:675	EKENQ	APC,CDC20,FZR1	0.5502	More...
P48681	Nestin	DEG_APCC_KENBOX_2	715:719	EKENQ	APC,CDC20,FZR1	0.9987	More...
Q15004	PCNA-associated factor	DEG_APCC_KENBOX_2	77:81	EKENQ	APC,CDC20,FZR1	0.9907	More...
Q16363	Laminin subunit alpha-4	DEG_APCC_KENBOX_2	358:362	EKENQ	APC,CDC20,FZR1	0.7882	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_APCC_KENBOX_2	10:14	EKENQ	APC,CDC20,FZR1	0.9404	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	2540:2544	EKENQ	APC,CDC20,FZR1	0.8952	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	1186:1190	EKENQ	APC,CDC20,FZR1	0.993	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	469:473	EKENQ	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons