DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_APCC_KENBOX_2

Location: 2540:2544

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8952

ASA_SCORE: 121.26

COIL: 0.7888

CONS_SCORE: 0.4729

DSS_SCORE: 0.5669

HELIX: 0.0758

FCONS_SCORE: 1.0506

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2554H	TCGA-WJ-A86L	LIHC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.Q2554H	DO52325	LIHC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.G2551E	DO222632	MELA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1389
p.G2551E	DO229456	SKCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1389
p.G2551E	DO37432	SKCM	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1389
p.S2533F	DO222678	MELA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30519	Heme oxygenase 2	DEG_APCC_KENBOX_2	23:27	EKENQ	APC,CDC20,FZR1	0.713	More...
P48681	Nestin	DEG_APCC_KENBOX_2	671:675	EKENQ	APC,CDC20,FZR1	0.5502	More...
P48681	Nestin	DEG_APCC_KENBOX_2	715:719	EKENQ	APC,CDC20,FZR1	0.9987	More...
Q15004	PCNA-associated factor	DEG_APCC_KENBOX_2	77:81	EKENQ	APC,CDC20,FZR1	0.9907	More...
Q16363	Laminin subunit alpha-4	DEG_APCC_KENBOX_2	358:362	EKENQ	APC,CDC20,FZR1	0.7882	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_APCC_KENBOX_2	10:14	EKENQ	APC,CDC20,FZR1	0.9404	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	2540:2544	EKENQ	APC,CDC20,FZR1	0.8952	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	1186:1190	EKENQ	APC,CDC20,FZR1	0.993	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	469:473	EKENQ	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons