DegronMD - Q8N3K9(CMYA5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P703S	TCGA-06-5416	GBM	TCGA	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation altering degron motif	0.6752
p.P703S	DO10880	GBM	ICGC	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation altering degron motif	0.6752
p.Y3726C	TCGA-13-1477	OV	TCGA	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.2222
p.Y3726C	DO27978	OV	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.2222
p.E1088K	TCGA-21-1079	LUSC	TCGA	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.E1088K	TCGA-C8-A26Y	BRCA	TCGA	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.E1088K	TCGA-W3-AA1V	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.E1088K	DO1273	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.E1088K	DO26846	LUSC	ICGC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.E1088K	DO51276	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.T3721K	TCGA-22-1016	LUSC	TCGA	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation altering degron motif	0.7306
p.T3721K	DO26971	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation altering degron motif	0.7306
p.S904L	TCGA-3N-A9WC	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1944
p.S904L	TCGA-EB-A3Y7	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1944
p.S904L	DO225215	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1944
p.S904L	DO227836	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1944
p.S904L	DO220886	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1944
p.S904L	DO37499	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1944
p.S904L	DO51234	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1944
p.S2368G	TCGA-4Z-AA80	BLCA	TCGA	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.2222
p.S2368G	DO218986	BLCA	ICGC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.2222
p.T3722A	TCGA-55-1594	LUAD	TCGA	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation altering degron motif	0.7139
p.T3722A	DO24722	LUAD	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation altering degron motif	0.7139
p.P519T	TCGA-55-6712	LUAD	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.7031
p.P519T	DO25310	LUAD	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.7031
p.V1103L	TCGA-55-A490	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2778
p.V1103L	DO24596	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2778
p.E529Q	TCGA-56-7730	LUSC	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1389
p.E529Q	DO26617	LUSC	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1389
p.V532I	TCGA-76-4926	GBM	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0556
p.V532I	DO12478	GBM	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0556
p.V532I	SIDM01293	Colorectal Carcinoma	GDSC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0556
p.P692Q	TCGA-77-6842	LUSC	TCGA	PDSTS	DEG_SPOP_SBC_1	692:696	Mutation altering degron motif	0.7035
p.P692Q	DO27413	LUSC	ICGC	PDSTS	DEG_SPOP_SBC_1	692:696	Mutation altering degron motif	0.7035
p.R3826W	TCGA-A5-A0VP	UCEC	TCGA	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.3056
p.R3826W	DO42600	UCEC	ICGC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.3056
p.E709Q	TCGA-AA-3511	COAD	TCGA	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation rewiring degron network	0.2222
p.E709Q	DO7804	COAD	ICGC	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation rewiring degron network	0.2222
p.K712N	TCGA-AA-3984	COAD	TCGA	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation substituting flanking lysine	0.25
p.K712N	DO9002	COAD	ICGC	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation substituting flanking lysine	0.25
p.S1842C	TCGA-AC-A23H	BRCA	TCGA	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation altering degron motif	0.7541
p.S1842C	DO2401	BRCA	ICGC	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation altering degron motif	0.7541
p.D523Y	TCGA-AG-A002	READ	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.3056
p.D523Y	DO222762	COCA	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.3056
p.A1090S	TCGA-AP-A056	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1389
p.A1090S	DO43971	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.1389
p.E1342K	TCGA-AP-A056	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation rewiring degron network	0.1389
p.E1342K	DO43971	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation rewiring degron network	0.1389
p.A887V	TCGA-AX-A1CE	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1111
p.A887V	DO42280	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1111
p.R2367I	TCGA-AX-A2HC	UCEC	TCGA	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.25
p.R2367I	DO41572	UCEC	ICGC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.25
p.L513I	TCGA-B5-A0K3	UCEC	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.2778
p.L513I	DO43314	UCEC	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.2778
p.E1346K	TCGA-BH-A0HF	BRCA	TCGA	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation rewiring degron network	0.25
p.E1346K	DO1749	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation rewiring degron network	0.25
p.A1356T	TCGA-BR-8078	STAD	TCGA	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation rewiring degron network	0.25
p.A1356T	DO38288	STAD	ICGC	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation rewiring degron network	0.25
p.S1357Y	TCGA-CA-6717	COAD	TCGA	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation blocking phosphorylation signal	0.6667
p.S1357Y	DO8264	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation blocking phosphorylation signal	0.6667
p.I531N	TCGA-D1-A103	UCEC	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.I531N	DO42312	UCEC	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.P1374T	TCGA-D3-A1Q3	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.0556
p.P1374T	DO47509	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.0556
p.K3012N	TCGA-D9-A6EC	SKCM	TCGA	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation substituting flanking lysine	0.3333
p.K3012N	DO50291	SKCM	ICGC	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation substituting flanking lysine	0.3333
p.S2360Y	TCGA-DK-A6AW	BLCA	TCGA	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation altering degron motif	0.6009
p.S2360Y	DO48566	BLCA	ICGC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation altering degron motif	0.6009
p.R892Q	TCGA-E6-A1LX	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.25
p.R892Q	DO41020	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.25
p.D1845N	TCGA-EB-A3XD	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation rewiring degron network	0.2778
p.D1845N	DO37871	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation rewiring degron network	0.2778
p.S1378F	TCGA-EE-A29D	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.1667
p.S1378F	TCGA-FW-A3R5	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.1667
p.S1378F	DO37406	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.1667
p.S1378F	DO38123	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.1667
p.E885K	TCGA-EE-A2GO	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0556
p.E885K	TCGA-JY-A93E	ESCA	TCGA	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0556
p.E885K	DO220903	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0556
p.E885K	DO222843	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0556
p.E885K	DO37823	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0556
p.K3005N	TCGA-EO-A3B0	UCEC	TCGA	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation substituting flanking lysine	0.2222
p.K3005N	DO219773	UCEC	ICGC	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation substituting flanking lysine	0.2222
p.D1848Y	TCGA-EY-A1GI	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation rewiring degron network	0.1944
p.D1848Y	DO41211	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation rewiring degron network	0.1944
p.S3717Y	TCGA-F5-6814	READ	TCGA	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.S3717Y	DO36556	READ	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.N3730S	TCGA-F7-A624	HNSC	TCGA	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1111
p.N3730S	DO44440	HNSC	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1111
p.S1377L	TCGA-FR-A729	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.1389
p.S1377L	DO48618	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.1389
p.R1385C	TCGA-FS-A1ZW	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.8301
p.R1385C	TCGA-XK-AAIW	PRAD	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.8301
p.R1385C	DO51407	PRAD	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.8301
p.R1385C	DO37519	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.8301
p.P895S	TCGA-FS-A4F8	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation altering degron motif	0.6752
p.P895S	DO38117	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation altering degron motif	0.6752
p.R2367K	TCGA-FW-A3R5	SKCM	TCGA	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.25
p.R2367K	DO37406	SKCM	ICGC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.25
p.E530K	TCGA-IB-7651	PAAD	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1111
p.E530K	DO46657	PAAD	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1111
p.S1843Y	TCGA-MN-A4N5	LUAD	TCGA	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation altering degron motif	0.712
p.S1843Y	DO45332	LUAD	ICGC	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation altering degron motif	0.712
p.E530G	TCGA-W3-A828	SKCM	TCGA	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1111
p.E530G	DO51273	SKCM	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1111
p.Q2554H	TCGA-WJ-A86L	LIHC	TCGA	EKENQ	DEG_APCC_KENBOX_2	2540:2544	Mutation rewiring degron network	0.0556
p.Q2554H	DO52325	LIHC	ICGC	EKENQ	DEG_APCC_KENBOX_2	2540:2544	Mutation rewiring degron network	0.0556
p.E889K	DO222884	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.1667
p.S1350R	DO228092	EOPC	ICGC	PSSST	DEG_SPOP_SBC_1	1349:1353	Mutation altering degron motif	0.7427
p.P3712S	DO234389	ESAD	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1667
p.P3712S	SIDM00944	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1667
p.P3712S	SIDM00453	Pancreatic Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1667
p.P3712S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1667
p.P3712S	SIDM01709	Melanoma	GDSC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1667
p.I531M	DO233900	GACA	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.S3006N	DO224559	LAML	ICGC	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.0556
p.S3006N	DO224559	LAML	ICGC	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation rewiring degron network	0.1389
p.R892L	DO228934	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.25
p.K1852N	DO229018	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation substituting flanking lysine	0.1944
p.A2350S	DO229026	LICA	ICGC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.0833
p.A3724S	DO229038	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.2778
p.A3821S	DO229009	LICA	ICGC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.1667
p.S512T	DO228883	LICA	ICGC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.25
p.Y908D	DO45057	LINC	ICGC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation rewiring degron network	0.0833
p.S2360P	DO228435	MALY	ICGC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation altering degron motif	0.5641
p.P2354L	DO222521	MELA	ICGC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.1944
p.G2551E	DO222632	MELA	ICGC	EKENQ	DEG_APCC_KENBOX_2	2540:2544	Mutation rewiring degron network	0.1389
p.G2551E	DO229456	SKCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	2540:2544	Mutation rewiring degron network	0.1389
p.G2551E	DO37432	SKCM	ICGC	EKENQ	DEG_APCC_KENBOX_2	2540:2544	Mutation rewiring degron network	0.1389
p.S2533F	DO222678	MELA	ICGC	EKENQ	DEG_APCC_KENBOX_2	2540:2544	Mutation rewiring degron network	0.1389
p.T1389P	DO229183	NKTL	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.5919
p.A3832V	DO232761	PBCA	ICGC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation altering degron motif	0.5825
p.W3727C	DO51134	PRAD	ICGC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.1944
p.D1848N	DO229462	SKCA	ICGC	VSTSS	DEG_SPOP_SBC_1	1839:1843	Mutation rewiring degron network	0.1944
p.A697T	SIDM02055	Colorectal Carcinoma	GDSC	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation altering degron motif	0.6028
p.P3708S	SIDM00499	Prostate Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.0556
p.P3708S	ACH-000956	Prostate Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.0556
p.P3708S	22RV1	prostate	COSMIC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.0556
p.A1110S	SIDM00313	Hodgkin's Lymphoma	GDSC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.A1110S	ACH-000702	Lymphoma	CCLE	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.A1110S	L-1236	haematopoietic and lymphoid tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.H3025D	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.1944
p.H3025D	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation rewiring degron network	0.1389
p.H3025D	ACH-000840	Lung Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.1944
p.H3025D	ACH-000840	Lung Cancer	CCLE	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation rewiring degron network	0.1389
p.H3025D	HCC-366	lung	COSMIC	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.1944
p.H3025D	HCC-366	lung	COSMIC	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation rewiring degron network	0.1389
p.R3826Q	SIDM00773	Non-Cancerous	GDSC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.3056
p.R3826Q	SIDM00846	Cervical Carcinoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.3056
p.R3826Q	SIDM00529	Breast Carcinoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.3056
p.R3826Q	SIDM00863	Burkitt's Lymphoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.3056
p.R3826Q	SIDM00257	Neuroblastoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.3056
p.V532G	SIDM00232	Kidney Carcinoma	GDSC	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0556
p.V532G	ACH-002168	Kidney Cancer	CCLE	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0556
p.P1374S	SIDM01184	Bladder Carcinoma	GDSC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.0556
p.P1374S	ACH-000018	Bladder Cancer	CCLE	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.0556
p.P1374S	T-24	urinary tract	COSMIC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation rewiring degron network	0.0556
p.T3837S	SIDM00187	Kidney Carcinoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.2222
p.T3837S	ACH-002150	Kidney Cancer	CCLE	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.2222
p.T3837S	LB1047-RCC	kidney	COSMIC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation rewiring degron network	0.2222
p.T3833M	SIDM00007	Other Solid Cancers	GDSC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation altering degron motif	0.7423
p.T3833M	ACH-001550	Skin Cancer	CCLE	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation altering degron motif	0.7423
p.T3833M	MCC13	skin	COSMIC	PTTPEAT	DEG_SCF_FBW7_1	3827:3833	Mutation altering degron motif	0.7423
p.E3030D	SIDM00193	Colorectal Carcinoma	GDSC	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.0556
p.E3030D	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.0556
p.E3030D	SNU-81	large intestine	COSMIC	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.0556
p.K3005E	SIDM00285	Neuroblastoma	GDSC	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation substituting flanking lysine	0.2222
p.K3005E	ACH-001338	Neuroblastoma	CCLE	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation substituting flanking lysine	0.2222
p.K3005E	CHP-134	autonomic ganglia	COSMIC	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation substituting flanking lysine	0.2222
p.S3717F	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.S3717F	ACH-000837	Lung Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.S3717F	NCI-H322M	lung	COSMIC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.T1101I	SIDM00806	Osteosarcoma	GDSC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.7078
p.T1101I	HOS	bone	COSMIC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation altering degron motif	0.7078
p.D1384E	SIDM01045	Endometrial Carcinoma	GDSC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.5647
p.D1384E	ACH-000978	Endometrial/Uterine Cancer	CCLE	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.5647
p.D1384E	EN	endometrium	COSMIC	DRPVLTKVG	DEG_APCC_DBOX_1	1384:1392	Mutation altering degron motif	0.5647
p.A1110V	SIDM00245	Small Cell Lung Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.A1110V	ACH-001131	Skin Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.A1110V	ACH-001958	lung	CCLE	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.A1110V	MS-1	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.0833
p.I3723T	SIDM01217	Other Blood Cancers	GDSC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.I3723T	ACH-002276	Leukemia	CCLE	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.I3723T	MY-M12	haematopoietic and lymphoid tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	3718:3722	Mutation rewiring degron network	0.3056
p.E1095D	SIDM00534	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2778
p.E1095D	ACH-000986	Colon/Colorectal Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2778
p.E1095D	HT-115	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation rewiring degron network	0.2778
p.P2353H	SIDM00118	Colorectal Carcinoma	GDSC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.1667
p.P2353H	ACH-001081	Colon/Colorectal Cancer	CCLE	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.1667
p.P2353H	HCC2998	large intestine	COSMIC	ISIFKE	LIG_APCC_ABBA_1	2359:2364	Mutation rewiring degron network	0.1667
p.S897F	SIDM01059	Melanoma	GDSC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation altering degron motif	0.7982
p.S897F	ACH-000915	Skin Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation altering degron motif	0.7982
p.S897F	IPC-298	skin	COSMIC	PSSTS	DEG_SPOP_SBC_1	895:899	Mutation altering degron motif	0.7982
p.E709D	SIDM00980	Gastric Carcinoma	GDSC	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation rewiring degron network	0.2222
p.E709D	ACH-000948	Gastric Cancer	CCLE	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation rewiring degron network	0.2222
p.E709D	23132-87	stomach	COSMIC	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation rewiring degron network	0.2222
p.S687R	SIDM01503	Small Cell Lung Carcinoma	GDSC	DSTSASEYSVPSL	DEG_COP1_1	693:705	Mutation blocking phosphorylation signal	0.6111
p.S687R	SIDM01503	Small Cell Lung Carcinoma	GDSC	PDSTS	DEG_SPOP_SBC_1	692:696	Mutation blocking phosphorylation signal	0.6389
p.K3012Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation substituting flanking lysine	0.3333
p.K3012Q	ACH-000925	Lung Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation substituting flanking lysine	0.3333
p.K1093N	ACH-000649	Kidney Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	1097:1101	Mutation substituting flanking lysine	0.3333
p.A516D	ACH-001518	Endometrial/Uterine Cancer	CCLE	IAITPEPE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.6682
p.T3024A	ACH-001610	Brain Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation rewiring degron network	0.2222
p.T3024A	ACH-001610	Brain Cancer	CCLE	VTPLKE	DEG_SCF_FBW7_2	3013:3018	Mutation rewiring degron network	0.1667
p.N3019S	ACH-001692	Head and Neck Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	3016:3020	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CMYA5

UniProt ID: Q8N3K9

Entrez ID: 202333

Protein name: Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CMYA5 in