DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_SCF_FBW7_1

Location: 3827:3833

E3 ligase: FBXW7

DEGRON score: 0.6223

ASA_SCORE: 68.5143

COIL: 0.8416

CONS_SCORE: 0.3916

DSS_SCORE: 0.3657

HELIX: 0.0233

FCONS_SCORE: 0.8404

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3826W	TCGA-A5-A0VP	UCEC	TCGA	PTTPEAT	DEG_SCF_FBW7_1	0.3056
p.R3826W	DO42600	UCEC	ICGC	PTTPEAT	DEG_SCF_FBW7_1	0.3056
p.A3821S	DO229009	LICA	ICGC	PTTPEAT	DEG_SCF_FBW7_1	0.1667
p.A3832V	DO232761	PBCA	ICGC	PTTPEAT	DEG_SCF_FBW7_1	0.5825
p.R3826Q	SIDM00773	Non-Cancerous	GDSC	PTTPEAT	DEG_SCF_FBW7_1	0.3056
p.R3826Q	SIDM00846	Cervical Carcinoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	0.3056
p.R3826Q	SIDM00529	Breast Carcinoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	0.3056
p.R3826Q	SIDM00863	Burkitt's Lymphoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	0.3056
p.R3826Q	SIDM00257	Neuroblastoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	0.3056
p.T3837S	SIDM00187	Kidney Carcinoma	GDSC	PTTPEAT	DEG_SCF_FBW7_1	0.2222
p.T3837S	ACH-002150	Kidney Cancer	CCLE	PTTPEAT	DEG_SCF_FBW7_1	0.2222
p.T3837S	LB1047-RCC	kidney	COSMIC	PTTPEAT	DEG_SCF_FBW7_1	0.2222
p.T3833M	SIDM00007	Other Solid Cancers	GDSC	PTTPEAT	DEG_SCF_FBW7_1	0.7423
p.T3833M	ACH-001550	Skin Cancer	CCLE	PTTPEAT	DEG_SCF_FBW7_1	0.7423
p.T3833M	MCC13	skin	COSMIC	PTTPEAT	DEG_SCF_FBW7_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SCF_FBW7_1	3827:3833	PTTPEAT	FBXW7	0.6223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons