DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: LIG_APCC_ABBA_1

Location: 2359:2364

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9205

ASA_SCORE: 101.4833

COIL: 0.862

CONS_SCORE: 0.4937

DSS_SCORE: 0.5374

HELIX: 0.0335

FCONS_SCORE: 1.1242

RIG_SCORE: 0.7944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2368G	TCGA-4Z-AA80	BLCA	TCGA	ISIFKE	LIG_APCC_ABBA_1	0.2222
p.S2368G	DO218986	BLCA	ICGC	ISIFKE	LIG_APCC_ABBA_1	0.2222
p.R2367I	TCGA-AX-A2HC	UCEC	TCGA	ISIFKE	LIG_APCC_ABBA_1	0.25
p.R2367I	DO41572	UCEC	ICGC	ISIFKE	LIG_APCC_ABBA_1	0.25
p.S2360Y	TCGA-DK-A6AW	BLCA	TCGA	ISIFKE	LIG_APCC_ABBA_1	0.6009
p.S2360Y	DO48566	BLCA	ICGC	ISIFKE	LIG_APCC_ABBA_1	0.6009
p.R2367K	TCGA-FW-A3R5	SKCM	TCGA	ISIFKE	LIG_APCC_ABBA_1	0.25
p.R2367K	DO37406	SKCM	ICGC	ISIFKE	LIG_APCC_ABBA_1	0.25
p.A2350S	DO229026	LICA	ICGC	ISIFKE	LIG_APCC_ABBA_1	0.0833
p.S2360P	DO228435	MALY	ICGC	ISIFKE	LIG_APCC_ABBA_1	0.5641
p.P2354L	DO222521	MELA	ICGC	ISIFKE	LIG_APCC_ABBA_1	0.1944
p.P2353H	SIDM00118	Colorectal Carcinoma	GDSC	ISIFKE	LIG_APCC_ABBA_1	0.1667
p.P2353H	ACH-001081	Colon/Colorectal Cancer	CCLE	ISIFKE	LIG_APCC_ABBA_1	0.1667
p.P2353H	HCC2998	large_intestine	COSMIC	ISIFKE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3K9	Cardiomyopathy-associated protein 5	LIG_APCC_ABBA_1	2359:2364	ISIFKE	APC,CDC20,FZR1	0.9205	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons