DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_SPOP_SBC_1

Location: 1097:1101

E3 ligase: SPOP

DEGRON score: 0.9044

ASA_SCORE: 87.98

COIL: 0.9286

CONS_SCORE: 0.3973

DSS_SCORE: 0.4307

HELIX: 0.0194

FCONS_SCORE: 1

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1088K	TCGA-21-1079	LUSC	TCGA	PTTST	DEG_SPOP_SBC_1	0.0833
p.E1088K	TCGA-C8-A26Y	BRCA	TCGA	PTTST	DEG_SPOP_SBC_1	0.0833
p.E1088K	TCGA-W3-AA1V	SKCM	TCGA	PTTST	DEG_SPOP_SBC_1	0.0833
p.E1088K	DO1273	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.E1088K	DO26846	LUSC	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.E1088K	DO51276	SKCM	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.V1103L	TCGA-55-A490	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.2778
p.V1103L	DO24596	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.2778
p.A1090S	TCGA-AP-A056	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	0.1389
p.A1090S	DO43971	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.1389
p.A1110S	SIDM00313	Hodgkin's Lymphoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.A1110S	ACH-000702	Lymphoma	CCLE	PTTST	DEG_SPOP_SBC_1	0.0833
p.A1110S	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PTTST	DEG_SPOP_SBC_1	0.0833
p.T1101I	SIDM00806	Osteosarcoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7078
p.T1101I	HOS	bone	COSMIC	PTTST	DEG_SPOP_SBC_1	0.7078
p.A1110V	SIDM00245	Small Cell Lung Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.A1110V	ACH-001131	Skin Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.0833
p.A1110V	ACH-001958	lung	CCLE	PTTST	DEG_SPOP_SBC_1	0.0833
p.A1110V	MS-1	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.0833
p.E1095D	SIDM00534	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.2778
p.E1095D	ACH-000986	Colon/Colorectal Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.2778
p.E1095D	HT-115	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.2778
p.K1093N	ACH-000649	Kidney Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons