DegronMD

Uniprot ID: Q8IZA0

Source protein: Dyslexia-associated protein KIAA0319-like protein

Source gene: KIAA0319L

Class: DEG_SPOP_SBC_1

Location: 422:426

E3 ligase: SPOP

DEGRON score: 0.7723

ASA_SCORE: 54.06

COIL: 0.541

CONS_SCORE: 0.6079

DSS_SCORE: 0.5303

HELIX: 0.0116

FCONS_SCORE: 1.1233

RIG_SCORE: 0.722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D435Y	TCGA-62-A46Y	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.0833
p.D435Y	DO48883	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.T434A	TCGA-B5-A11E	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	0.1111
p.T434A	DO41644	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.1111
p.D429Y	TCGA-BS-A0UF	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	0.25
p.D429Y	DO41488	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.25
p.S413P	TCGA-EO-A22X	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	0.0833
p.S413P	DO43907	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.I419N	TCGA-OL-A5D7	BRCA	TCGA	PTTST	DEG_SPOP_SBC_1	0.25
p.I419N	DO44113	BRCA	ICGC	PTTST	DEG_SPOP_SBC_1	0.25
p.S420C	TCGA-VS-A953	CESC	TCGA	PTTST	DEG_SPOP_SBC_1	0.2778
p.S420C	DO219727	CESC	ICGC	PTTST	DEG_SPOP_SBC_1	0.2778
p.A424E	DO229029	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.7701
p.T426K	DO229031	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.7306
p.R423Q	DO51762	STAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.7329
p.D435V	SIDM01197	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.0833
p.D435V	ACH-000722	Colon/Colorectal Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.0833
p.D435V	SNU-C1	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons