DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 885:889

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 79.04

COIL: 0.7042

CONS_SCORE: 0.4097

DSS_SCORE: 0.4956

HELIX: 0.0206

FCONS_SCORE: 1.0866

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K878E	TCGA-55-7725	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	0.25
p.K878E	DO24636	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	0.25
p.R898G	TCGA-B5-A3FC	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	0.0833
p.R898G	DO41871	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.0833
p.S888T	TCGA-CC-A7IG	LIHC	TCGA	PTTST	DEG_SPOP_SBC_1	0.6005
p.S888T	DO52179	LIHC	ICGC	PTTST	DEG_SPOP_SBC_1	0.6005
p.S895L	TCGA-CV-A6K2	HNSC	TCGA	PTTST	DEG_SPOP_SBC_1	0.1667
p.S895L	DO52079	HNSC	ICGC	PTTST	DEG_SPOP_SBC_1	0.1667
p.D899Y	TCGA-EO-A22R	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	0.0556
p.D899Y	DO42713	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	0.0556
p.A892S	DO229041	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.25
p.Q884L	DO23516	LIRI	ICGC	PTTST	DEG_SPOP_SBC_1	0.3056
p.T889I	SIDM00493	Other Solid Cancers	GDSC	PTTST	DEG_SPOP_SBC_1	0.7078
p.S895P	SIDM01140	Ovarian Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.1667
p.S895P	ACH-001374	Ovarian Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.1667
p.S895P	PA-1	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1667
p.T880A	ACH-000586	Lung Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.1944
p.T880A	NCI-H1876	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1944
p.P895Q	NCI-H358	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1667
p.E878G	H3255	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	0.25
p.P885L	COLO-678	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.7582
p.H886Q	769-P	kidney	COSMIC	PTTST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons