DegronMD

Uniprot ID: Q96GD3

Source protein: Polycomb protein SCMH1

Source gene: SCMH1

Class: DEG_SPOP_SBC_1

Location: 330:334

E3 ligase: SPOP

DEGRON score: 0.7052

ASA_SCORE: 84.18

COIL: 0.9412

CONS_SCORE: 0.4344

DSS_SCORE: 0.8244

HELIX: 0.0194

FCONS_SCORE: 0.9385

RIG_SCORE: 0.5151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S325N	DO233652	GACA	ICGC	PTTST	DEG_SPOP_SBC_1	0.1944
p.G324S	DO233752	GACA	ICGC	PTTST	DEG_SPOP_SBC_1	0.1667
p.L333M	DO228978	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.711
p.T342N	DO228985	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	0.1111
p.P323S	DO222494	MELA	ICGC	PTTST	DEG_SPOP_SBC_1	0.1389
p.S333N	SIDM00216	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	0.7069
p.S333N	ACH-000989	Colon/Colorectal Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	0.7069
p.S333N	SNU-175	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.7069
p.S343N	SNU-175	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.0833
p.R342H	5637	urinary_tract	COSMIC	PTTST	DEG_SPOP_SBC_1	0.1111
p.R343L	HeLa	cervix	COSMIC	PTTST	DEG_SPOP_SBC_1	0.0833
p.A336T	ECC12	stomach	COSMIC	PTTST	DEG_SPOP_SBC_1	0.2778
p.A329V	RKO	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.3056
p.R328H	5637	urinary_tract	COSMIC	PTTST	DEG_SPOP_SBC_1	0.2778
p.K328E	SW48	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.2778
p.A343V	RKO	large_intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	885:889	PTTST	SPOP	0.9985	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	527:531	PTTST	SPOP	0.9979	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	234:238	PTTST	SPOP	0.8906	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1424:1428	PTTST	SPOP	0.6708	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3128:3132	PTTST	SPOP	0.5488	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3811:3815	PTTST	SPOP	0.6407	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3827:3831	PTTST	SPOP	0.5591	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1621:1625	PTTST	SPOP	0.9682	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	170:174	PTTST	SPOP	0.7765	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	422:426	PTTST	SPOP	0.7723	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1097:1101	PTTST	SPOP	0.9044	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12198:12202	PTTST	SPOP	0.9133	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	330:334	PTTST	SPOP	0.7052	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	375:379	PTTST	SPOP	0.9537	More...
Q99715	Collagen alpha-1	DEG_SPOP_SBC_1	825:829	PTTST	SPOP	0.9873	More...
A6NHQ4	Elongin BC and Polycomb repressive complex 2-associated protein	DEG_SPOP_SBC_1	308:312	PTTST	SPOP	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons