DegronMD - Q96GD3(SCMH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P516L	TCGA-D3-A5GR	SKCM	TCGA	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.1111
p.P516S	TCGA-D3-A5GR	SKCM	TCGA	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.1111
p.T341N	TCGA-EO-A22R	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7055
p.F493L	TCGA-XM-A8RG	THYM	TCGA	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.0556
p.S502F	TCGA-YL-A8SK	PRAD	TCGA	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.3056
p.P515T	DO233202	GACA	ICGC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.1389
p.S325N	DO233652	GACA	ICGC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1944
p.G324S	DO233752	GACA	ICGC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1667
p.L333M	DO228978	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.711
p.T342N	DO228985	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1111
p.T342N	DO228985	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.H516N	DO229022	LICA	ICGC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.1111
p.P515Q	DO229036	LICA	ICGC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.1389
p.S493R	DO229038	LICA	ICGC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.0556
p.P323S	DO222494	MELA	ICGC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.S512F	DO51433	PRAD	ICGC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.2222
p.H494R	DO223662	PRAD	ICGC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.0833
p.T351N	DO42713	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0556
p.S333N	SIDM00216	Colorectal Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.7069
p.S333N	ACH-000989	Colon/Colorectal Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.7069
p.S333N	SNU-175	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.7069
p.R501L	SIDM00846	Cervical Carcinoma	GDSC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.2778
p.R501L	ACH-001086	Cervical Cancer	CCLE	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.2778
p.R501L	HeLa	cervix	COSMIC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.2778
p.R501C	SIDM00171	Colorectal Carcinoma	GDSC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.2778
p.R501C	ACH-000412	Colon/Colorectal Cancer	CCLE	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.2778
p.S343N	SNU-175	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0833
p.S343N	SNU-175	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.R342H	5637	urinary tract	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1111
p.R342H	5637	urinary tract	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.R343L	HeLa	cervix	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0833
p.R343L	HeLa	cervix	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.A336T	ECC12	stomach	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.A336T	ECC12	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.3056
p.R511L	HeLa	cervix	COSMIC	LEPHSD	LIG_APCC_ABBA_1	503:508	Mutation rewiring degron network	0.25
p.A329V	RKO	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.3056
p.A329V	RKO	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1111
p.R328H	5637	urinary tract	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.R328H	5637	urinary tract	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.K328E	SW48	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.K328E	SW48	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.A343V	RKO	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0833
p.A343V	RKO	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2778
p.A350T	ECC12	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCMH1

UniProt ID: Q96GD3

Entrez ID: 22955

Protein name: Polycomb protein SCMH1 (Sex comb on midleg homolog 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCMH1 in