DegronMD

Uniprot ID: Q96GD3

Source protein: Polycomb protein SCMH1

Source gene: SCMH1

Class: LIG_APCC_ABBA_1

Location: 503:508

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8358

ASA_SCORE: 90.55

COIL: 0.8672

CONS_SCORE: 0.3627

DSS_SCORE: 0.5519

HELIX: 0.0977

FCONS_SCORE: 1.1161

RIG_SCORE: 0.6375

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P516L	TCGA-D3-A5GR	SKCM	TCGA	LEPHSD	LIG_APCC_ABBA_1	0.1111
p.P516S	TCGA-D3-A5GR	SKCM	TCGA	LEPHSD	LIG_APCC_ABBA_1	0.1111
p.F493L	TCGA-XM-A8RG	THYM	TCGA	LEPHSD	LIG_APCC_ABBA_1	0.0556
p.S502F	TCGA-YL-A8SK	PRAD	TCGA	LEPHSD	LIG_APCC_ABBA_1	0.3056
p.P515T	DO233202	GACA	ICGC	LEPHSD	LIG_APCC_ABBA_1	0.1389
p.H516N	DO229022	LICA	ICGC	LEPHSD	LIG_APCC_ABBA_1	0.1111
p.P515Q	DO229036	LICA	ICGC	LEPHSD	LIG_APCC_ABBA_1	0.1389
p.S493R	DO229038	LICA	ICGC	LEPHSD	LIG_APCC_ABBA_1	0.0556
p.S512F	DO51433	PRAD	ICGC	LEPHSD	LIG_APCC_ABBA_1	0.2222
p.H494R	DO223662	PRAD	ICGC	LEPHSD	LIG_APCC_ABBA_1	0.0833
p.R501L	SIDM00846	Cervical Carcinoma	GDSC	LEPHSD	LIG_APCC_ABBA_1	0.2778
p.R501L	ACH-001086	Cervical Cancer	CCLE	LEPHSD	LIG_APCC_ABBA_1	0.2778
p.R501L	HeLa	cervix	COSMIC	LEPHSD	LIG_APCC_ABBA_1	0.2778
p.R501C	SIDM00171	Colorectal Carcinoma	GDSC	LEPHSD	LIG_APCC_ABBA_1	0.2778
p.R501C	ACH-000412	Colon/Colorectal Cancer	CCLE	LEPHSD	LIG_APCC_ABBA_1	0.2778
p.R511L	HeLa	cervix	COSMIC	LEPHSD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GD3	Polycomb protein SCMH1	LIG_APCC_ABBA_1	503:508	LEPHSD	APC,CDC20,FZR1	0.8358	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons