DegronMD

Uniprot ID: Q96GD3

Source protein: Polycomb protein SCMH1

Source gene: SCMH1

Class: DEG_SPOP_SBC_1

Location: 337:341

E3 ligase: SPOP

DEGRON score: 0.9895

ASA_SCORE: 86.18

COIL: 0.896

CONS_SCORE: 0.5599

DSS_SCORE: 0.7439

HELIX: 0.0606

FCONS_SCORE: 1.3481

RIG_SCORE: 0.6192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T341N	TCGA-EO-A22R	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.7055
p.T342N	DO228985	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.3056
p.T351N	DO42713	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.S343N	SNU-175	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.2778
p.R342H	5637	urinary_tract	COSMIC	PDTST	DEG_SPOP_SBC_1	0.3056
p.R343L	HeLa	cervix	COSMIC	PDTST	DEG_SPOP_SBC_1	0.2778
p.A336T	ECC12	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	0.3056
p.A329V	RKO	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.1111
p.R328H	5637	urinary_tract	COSMIC	PDTST	DEG_SPOP_SBC_1	0.0833
p.K328E	SW48	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.0833
p.A343V	RKO	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.2778
p.A350T	ECC12	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons