DegronMD - Q8NDL9(AGBL5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R618Q	TCGA-A5-A2K5	UCEC	TCGA	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6218
p.R618Q	TCGA-ZB-A966	THYM	TCGA	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6218
p.R618Q	DO41379	UCEC	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6218
p.R618Q	SIDM00955	Melanoma	GDSC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6218
p.R618Q	ACH-000812	Skin Cancer	CCLE	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6218
p.R618Q	COLO-783	skin	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation altering degron motif	0.6218
p.R223H	TCGA-A6-6648	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.R223H	TCGA-CM-4746	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.R223H	TCGA-DM-A1HB	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.R223H	TCGA-KK-A6E6	PRAD	TCGA	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.R223H	DO10196	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.R223H	DO7882	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.R223H	DO51361	PRAD	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.R713H	TCGA-BR-4361	STAD	TCGA	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.0556
p.R713H	DO38887	STAD	ICGC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.0556
p.R713H	SIDM01099	Neuroblastoma	GDSC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.0556
p.R713H	ACH-000341	Neuroblastoma	CCLE	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.0556
p.R713H	SK-N-FI	autonomic ganglia	COSMIC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.0556
p.R238C	TCGA-D1-A17Q	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1944
p.R238C	DO41903	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1944
p.L607M	TCGA-DA-A1IB	SKCM	TCGA	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.0556
p.L607M	DO38033	SKCM	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.0556
p.A240V	TCGA-DU-6392	LGG	TCGA	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.A240V	DO22237	LGG	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389
p.R238S	TCGA-EE-A20F	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1944
p.R238S	DO37961	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1944
p.S632Y	TCGA-RC-A7S9	LIHC	TCGA	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation blocking phosphorylation signal	0.5278
p.S632Y	DO52309	LIHC	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation blocking phosphorylation signal	0.5278
p.A719T	DO222752	COCA	ICGC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.2222
p.A719T	DO233624	GACA	ICGC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.2222
p.P729L	DO222462	ESCA	ICGC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.2778
p.G626W	DO233156	GACA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.25
p.E633K	DO233286	GACA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.0556
p.V629F	DO228971	LICA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.P628H	DO229040	LICA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1944
p.P229S	DO229061	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation altering degron motif	0.6752
p.R223L	DO229009	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.G716E	DO232224	PBCA	ICGC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1389
p.G610V	DO229213	THCA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1389
p.H713Y	DO40801	UCEC	ICGC	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.0556
p.R238H	SIDM00541	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1944
p.S630F	SIDM00767	Small Cell Lung Carcinoma	GDSC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1389
p.S630F	ACH-001136	Lung Cancer	CCLE	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1389
p.S630F	NCI-H187	lung	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1389
p.K613E	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation substituting flanking lysine	0.3333
p.K613E	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation substituting flanking lysine	0.3333
p.V629I	SIDM00574	Glioblastoma	GDSC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.V629I	ACH-001605	Brain Cancer	CCLE	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.V629I	no-10	central nervous system	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	617:623	Mutation rewiring degron network	0.1667
p.R220Q	SIDM01111	Ewing's Sarcoma	GDSC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.0833
p.R220Q	ACH-000087	Bone Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.0833
p.R220Q	SK-ES-1	bone	COSMIC	PDTST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.0833
p.A730T	ACH-001099	Rhabdoid	CCLE	APTSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.25

Kaplan plot for AGBL5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGBL5

UniProt ID: Q8NDL9

Entrez ID: 60509

Protein name: Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGBL5 in