DegronMD

Uniprot ID: Q8NDL9

Source protein: Cytosolic carboxypeptidase-like protein 5

Source gene: AGBL5

Class: DEG_SCF_FBW7_1

Location: 617:623

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 109.0286

COIL: 0.9443

CONS_SCORE: 0.3435

DSS_SCORE: 0.6279

HELIX: 0.0231

FCONS_SCORE: 1.1043

RIG_SCORE: 0.6361

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R618Q	TCGA-A5-A2K5	UCEC	TCGA	LRTPPKS	DEG_SCF_FBW7_1	0.6218
p.R618Q	TCGA-ZB-A966	THYM	TCGA	LRTPPKS	DEG_SCF_FBW7_1	0.6218
p.R618Q	DO41379	UCEC	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.6218
p.R618Q	SIDM00955	Melanoma	GDSC	LRTPPKS	DEG_SCF_FBW7_1	0.6218
p.R618Q	ACH-000812	Skin Cancer	CCLE	LRTPPKS	DEG_SCF_FBW7_1	0.6218
p.R618Q	COLO-783	skin	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	0.6218
p.S632Y	TCGA-RC-A7S9	LIHC	TCGA	LRTPPKS	DEG_SCF_FBW7_1	0.5278
p.S632Y	DO52309	LIHC	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.5278
p.K613E	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LRTPPKS	DEG_SCF_FBW7_1	0.3333
p.K613E	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	0.3333
p.G626W	DO233156	GACA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.25
p.P628H	DO229040	LICA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.1944
p.V629F	DO228971	LICA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.1667
p.V629I	SIDM00574	Glioblastoma	GDSC	LRTPPKS	DEG_SCF_FBW7_1	0.1667
p.V629I	ACH-001605	Brain Cancer	CCLE	LRTPPKS	DEG_SCF_FBW7_1	0.1667
p.V629I	no-10	central_nervous_system	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	0.1667
p.G610V	DO229213	THCA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.1389
p.S630F	SIDM00767	Small Cell Lung Carcinoma	GDSC	LRTPPKS	DEG_SCF_FBW7_1	0.1389
p.S630F	ACH-001136	Lung Cancer	CCLE	LRTPPKS	DEG_SCF_FBW7_1	0.1389
p.S630F	NCI-H187	lung	COSMIC	LRTPPKS	DEG_SCF_FBW7_1	0.1389
p.L607M	TCGA-DA-A1IB	SKCM	TCGA	LRTPPKS	DEG_SCF_FBW7_1	0.0556
p.L607M	DO38033	SKCM	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.0556
p.E633K	DO233286	GACA	ICGC	LRTPPKS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SCF_FBW7_1	617:623	LRTPPKS	FBXW7	0.9978	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons