DegronMD

Uniprot ID: Q8NDL9

Source protein: Cytosolic carboxypeptidase-like protein 5

Source gene: AGBL5

Class: DEG_SPOP_SBC_1

Location: 229:233

E3 ligase: SPOP

DEGRON score: 0.8141

ASA_SCORE: 81.68

COIL: 0.9128

CONS_SCORE: 0.5221

DSS_SCORE: 0.4424

HELIX: 0.0594

FCONS_SCORE: 1.0435

RIG_SCORE: 0.7323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R223H	TCGA-A6-6648	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1667
p.R223H	TCGA-CM-4746	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1667
p.R223H	TCGA-DM-A1HB	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1667
p.R223H	TCGA-KK-A6E6	PRAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1667
p.R223H	DO10196	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.R223H	DO7882	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.R223H	DO51361	PRAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.R238C	TCGA-D1-A17Q	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	0.1944
p.R238C	DO41903	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.1944
p.A240V	TCGA-DU-6392	LGG	TCGA	PDTST	DEG_SPOP_SBC_1	0.1389
p.A240V	DO22237	LGG	ICGC	PDTST	DEG_SPOP_SBC_1	0.1389
p.R238S	TCGA-EE-A20F	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.1944
p.R238S	DO37961	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.1944
p.P229S	DO229061	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.6752
p.R223L	DO229009	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.R238H	SIDM00541	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.1944
p.R220Q	SIDM01111	Ewing's Sarcoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.0833
p.R220Q	ACH-000087	Bone Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.0833
p.R220Q	SK-ES-1	bone	COSMIC	PDTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons