DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 236:240

E3 ligase: SPOP

DEGRON score: 0.9814

ASA_SCORE: 96.5

COIL: 0.9576

CONS_SCORE: 0.5042

DSS_SCORE: 0.6399

HELIX: 0.0172

FCONS_SCORE: 1.0467

RIG_SCORE: 0.6585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S249F	TCGA-Q1-A73O	CESC	TCGA	PDTST	DEG_SPOP_SBC_1	0.0833
p.S249F	DO51612	CESC	ICGC	PDTST	DEG_SPOP_SBC_1	0.0833
p.L226F	DO229025	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.K232N	DO229024	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.3333
p.D237Y	DO229009	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.6214
p.P236R	SIDM00761	Small Cell Lung Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.7512
p.P236R	ACH-000752	Lung Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.7512
p.P236R	NCI-H196	lung	COSMIC	PDTST	DEG_SPOP_SBC_1	0.7512
p.P236H	SIDM00980	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.7694
p.P236H	ACH-000948	Gastric Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.7694
p.P236H	23132-87	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	0.7694
p.T241P	ACH-001669	Leukemia	CCLE	PDTST	DEG_SPOP_SBC_1	0.3056
p.T241P	ACH-002238	Leukemia	CCLE	PDTST	DEG_SPOP_SBC_1	0.3056
p.T241P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	0.3056
p.A250T	SK-MEL-24	skin	COSMIC	PDTST	DEG_SPOP_SBC_1	0.0556
p.T246N	BT-474	breast	COSMIC	PDTST	DEG_SPOP_SBC_1	0.1667
p.N238S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	0.7069
p.N236S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons