DegronMD - P52756(RBM5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E466V	TCGA-17-Z033	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1944
p.A406V	TCGA-2W-A8YY	CESC	TCGA	AVTTT	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.2778
p.A406V	DO223732	CESC	ICGC	AVTTT	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.2778
p.R64C	TCGA-3R-A8YX	SARC	TCGA	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0833
p.R64C	DO219943	SARC	ICGC	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0833
p.S97G	TCGA-85-7696	LUSC	TCGA	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.0833
p.S97G	DO26671	LUSC	ICGC	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.0833
p.L551F	TCGA-A1-A0SI	BRCA	TCGA	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.25
p.L551F	DO1774	BRCA	ICGC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.25
p.D90N	TCGA-AA-3684	COAD	TCGA	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.2778
p.D90N	DO8802	COAD	ICGC	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.2778
p.P445S	TCGA-AF-A56N	READ	TCGA	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.0833
p.P445S	DO50277	READ	ICGC	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.0833
p.Y54C	TCGA-AP-A054	UCEC	TCGA	DYR	CBL_MET	53:55	Mutation altering degron motif	0.8198
p.Y54C	DO42256	UCEC	ICGC	DYR	CBL_MET	53:55	Mutation altering degron motif	0.8198
p.R546H	TCGA-AX-A1CE	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.1111
p.R546H	DO234171	ESAD	ICGC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.1111
p.R546H	DO42280	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.1111
p.P423S	TCGA-AX-A2HD	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.0833
p.P423S	TCGA-EE-A20C	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.0833
p.P423S	DO47665	SKCM	ICGC	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.0833
p.P423S	DO42608	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.0833
p.D56Y	TCGA-B5-A1MR	UCEC	TCGA	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.3056
p.D56Y	DO41758	UCEC	ICGC	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.3056
p.S550I	TCGA-B5-A3FC	UCEC	TCGA	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.2222
p.S550I	DO41871	UCEC	ICGC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.2222
p.S567F	TCGA-BF-A5ES	SKCM	TCGA	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.0833
p.S567F	DO219456	SKCM	ICGC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.0833
p.R46Q	TCGA-BR-8078	STAD	TCGA	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.1389
p.R46Q	DO38288	STAD	ICGC	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.1389
p.D458N	TCGA-CK-4951	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.5821
p.D458N	DO10582	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.5821
p.S394L	TCGA-CR-6488	HNSC	TCGA	AVTTT	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1667
p.S394L	DO14368	HNSC	ICGC	AVTTT	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1667
p.E65D	TCGA-CV-7568	HNSC	TCGA	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0556
p.E65D	DO14160	HNSC	ICGC	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0556
p.K559E	TCGA-D3-A3ML	SKCM	TCGA	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.3056
p.K559E	DO47413	SKCM	ICGC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.3056
p.L568F	TCGA-DR-A0ZM	CESC	TCGA	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.0556
p.L568F	DO6254	CESC	ICGC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.0556
p.S97N	TCGA-DU-6407	LGG	TCGA	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.0833
p.S97N	DO22295	LGG	ICGC	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.0833
p.Y54D	TCGA-DW-7836	KIRP	TCGA	DYR	CBL_MET	53:55	Mutation altering degron motif	0.8436
p.Y54D	DO20847	KIRP	ICGC	DYR	CBL_MET	53:55	Mutation altering degron motif	0.8436
p.Q463K	TCGA-EE-A183	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.2778
p.Q463K	DO37715	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.2778
p.P426S	TCGA-EE-A2M5	SKCM	TCGA	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1667
p.I91M	TCGA-EK-A3GK	CESC	TCGA	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.25
p.I91M	DO49964	CESC	ICGC	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.25
p.Y54H	TCGA-EO-A22R	UCEC	TCGA	DYR	CBL_MET	53:55	Mutation altering degron motif	0.834
p.Y54H	DO42713	UCEC	ICGC	DYR	CBL_MET	53:55	Mutation altering degron motif	0.834
p.K502N	TCGA-EO-A3B0	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	509:513	Mutation substituting flanking lysine	0.25
p.K502N	DO219773	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	509:513	Mutation substituting flanking lysine	0.25
p.A443T	TCGA-HF-7133	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1389
p.A443T	DO38819	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1389
p.R55Q	TCGA-HU-A4GX	STAD	TCGA	DYR	CBL_MET	53:55	Mutation altering degron motif	0.7329
p.R55Q	DO47757	STAD	ICGC	DYR	CBL_MET	53:55	Mutation altering degron motif	0.7329
p.D90A	TCGA-VQ-A8PP	STAD	TCGA	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.2778
p.D90A	DO51774	STAD	ICGC	DYR	CBL_MET	86:88	Mutation rewiring degron network	0.2778
p.S511F	TCGA-VR-A8ER	ESCA	TCGA	AESSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.7982
p.G447S	DO223439	CLLE	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0556
p.Y462D	DO228932	COCA	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.3056
p.G451C	DO228948	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1667
p.G451C	DO229029	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1667
p.G518V	DO228971	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.1944
p.E63D	DO228986	LICA	ICGC	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.1111
p.G500V	DO229019	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.0833
p.A508S	DO229019	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.3056
p.A400S	DO229029	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	400:404	Mutation altering degron motif	0.7588
p.D86Y	DO229022	LICA	ICGC	DYR	CBL_MET	86:88	Mutation altering degron motif	0.7325
p.S395F	DO26434	LUSC	ICGC	AVTTT	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1944
p.PP422PS	DO222775	MELA	ICGC	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0
p.K453T	DO227633	PACA	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation substituting flanking lysine	0.3333
p.Y471H	DO229538	PRAD	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0556
p.Q516K	DO229275	THCA	ICGC	AESSS	DEG_SPOP_SBC_1	509:513	Mutation rewiring degron network	0.25
p.D465G	DO229211	THCA	ICGC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.2222
p.G424D	SIDM00572	Gastric Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1111
p.G424D	ACH-000911	Gastric Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1111
p.G424D	NUGC-3	stomach	COSMIC	PSTST	DEG_SPOP_SBC_1	432:436	Mutation rewiring degron network	0.1111
p.S561N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.25
p.S561N	ACH-002256	Leukemia	CCLE	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.25
p.S561N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	QKENF	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.25
p.S43G	SIDM00905	Cervical Carcinoma	GDSC	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0556
p.S43G	ACH-001334	Cervical Cancer	CCLE	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0556
p.S43G	ACH-001335	Cervical Cancer	CCLE	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0556
p.S43G	C-4-I	cervix	COSMIC	DYR	CBL_MET	53:55	Mutation rewiring degron network	0.0556
p.P457S	SIDM00534	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.6752
p.P457S	ACH-000986	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.6752
p.P457S	HT-115	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.6752
p.Y57C	SIDM01473	Plasma Cell Myeloma	GDSC	DYR	CBL_MET	53:55	Mutation blocking phosphorylation signal	0.7222
p.S513Y	ACH-000594	Lung Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	509:513	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM5

UniProt ID: P52756

Entrez ID: 10181

Protein name: RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM5 in