DegronMD

Uniprot ID: P52756

Source protein: RNA-binding protein 5

Source gene: RBM5

Class: DEG_SPOP_SBC_1

Location: 457:461

E3 ligase: SPOP

DEGRON score: 0.9481

ASA_SCORE: 62.16

COIL: 0.759

CONS_SCORE: 0.2972

DSS_SCORE: 0.4517

HELIX: 0.0778

FCONS_SCORE: 0.7939

RIG_SCORE: 0.7696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E466V	TCGA-17-Z033	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.1944
p.D458N	TCGA-CK-4951	COAD	TCGA	PDTST	DEG_SPOP_SBC_1	0.5821
p.D458N	DO10582	COAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.5821
p.Q463K	TCGA-EE-A183	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	0.2778
p.Q463K	DO37715	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.2778
p.G447S	DO223439	CLLE	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.Y462D	DO228932	COCA	ICGC	PDTST	DEG_SPOP_SBC_1	0.3056
p.G451C	DO228948	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.G451C	DO229029	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1667
p.K453T	DO227633	PACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.3333
p.Y471H	DO229538	PRAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.0556
p.D465G	DO229211	THCA	ICGC	PDTST	DEG_SPOP_SBC_1	0.2222
p.P457S	SIDM00534	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.6752
p.P457S	ACH-000986	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.6752
p.P457S	HT-115	large_intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons