DegronMD

Uniprot ID: Q8N9M1

Source protein: Uncharacterized protein C19orf47

Source gene: C19orf47

Class: DEG_SPOP_SBC_1

Location: 160:164

E3 ligase: SPOP

DEGRON score: 0.9381

ASA_SCORE: 92.2

COIL: 0.9296

CONS_SCORE: 0.3462

DSS_SCORE: 0.729

HELIX: 0.0408

FCONS_SCORE: 0.8315

RIG_SCORE: 0.6068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R157H	DO218693	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	0.25
p.Q163K	DO229035	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	0.6944
p.L169F	DO222653	MELA	ICGC	PDTST	DEG_SPOP_SBC_1	0.1944
p.R157S	DO37896	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	0.25
p.R155C	DO38619	STAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.6389
p.T172M	DO38268	STAD	ICGC	PDTST	DEG_SPOP_SBC_1	0.5556
p.K167N	DO52412	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.25
p.Q164H	DO52402	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.7582
p.R155H	DO42504	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.6389
p.R155H	DO41452	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	0.6389
p.S168L	SIDM02026	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.S168L	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.2222
p.S168L	ACH-000664	Lymphoma	CCLE	PDTST	DEG_SPOP_SBC_1	0.2222
p.R159L	SIDM01194	Hepatocellular Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.3056
p.P160L	SIDM00217	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	0.7582
p.P160L	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	2035:2039	PDTST	SPOP	0.9975	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	457:461	PDTST	SPOP	0.9481	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SPOP_SBC_1	1274:1278	PDTST	SPOP	0.8975	More...
Q8NDL9	Cytosolic carboxypeptidase-like protein 5	DEG_SPOP_SBC_1	229:233	PDTST	SPOP	0.8141	More...
Q8WZ75	Roundabout homolog 4	DEG_SPOP_SBC_1	576:580	PDTST	SPOP	0.9187	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	1140:1144	PDTST	SPOP	0.9558	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	236:240	PDTST	SPOP	0.9814	More...
Q96GD3	Polycomb protein SCMH1	DEG_SPOP_SBC_1	337:341	PDTST	SPOP	0.9895	More...
Q96LR2	Leucine rich adaptor protein 1	DEG_SPOP_SBC_1	131:135	PDTST	SPOP	0.9852	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	676:680	PDTST	SPOP	0.9536	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	801:805	PDTST	SPOP	0.9687	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.9775	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5006	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	315:319	PDTST	SPOP	0.5384	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	160:164	PDTST	SPOP	0.9381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons