DegronMD - Q8N9M1(C19orf47)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A251S	TCGA-A5-A0GW	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7588
p.G246D	TCGA-CJ-5677	KIRC	TCGA	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1944
p.R265C	TCGA-EO-A22U	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.Q241E	DO6718	CLLE	ICGC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.A250T	DO234199	ESAD	ICGC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation blocking ubiquitination signal	0.75
p.R157H	DO218693	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.25
p.R264H	DO228197	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0833
p.R264H	DO41871	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0833
p.A248P	DO228985	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.25
p.Q163K	DO229035	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation altering degron motif	0.6944
p.P242T	DO229008	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0833
p.R263L	DO23834	LUAD	ICGC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1111
p.L169F	DO222653	MELA	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.1944
p.R157S	DO37896	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.25
p.R155C	DO38619	STAD	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation blocking phosphorylation signal	0.6389
p.T172M	DO38268	STAD	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation blocking phosphorylation signal	0.5556
p.K167N	DO52412	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.25
p.Q164H	DO52402	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation altering degron motif	0.7582
p.R155H	DO42504	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation blocking phosphorylation signal	0.6389
p.R155H	DO41452	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation blocking phosphorylation signal	0.6389
p.S168L	SIDM02026	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.S168L	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.S168L	ACH-000664	Lymphoma	CCLE	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.2222
p.R244H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389
p.R244H	ACH-002256	Leukemia	CCLE	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389
p.R159L	SIDM01194	Hepatocellular Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.3056
p.V241A	SIDM01045	Endometrial Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.V241A	ACH-000978	Endometrial/Uterine Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.P160L	SIDM00217	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	160:164	Mutation altering degron motif	0.7582
p.P160L	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	160:164	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C19orf47

UniProt ID: Q8N9M1

Entrez ID: 126526

Protein name: Uncharacterized protein C19orf47

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C19orf47 in