DegronMD

Uniprot ID: Q8N9M1

Source protein: Uncharacterized protein C19orf47

Source gene: C19orf47

Class: DEG_SPOP_SBC_1

Location: 251:255

E3 ligase: SPOP

DEGRON score: 0.9047

ASA_SCORE: 90.32

COIL: 0.8646

CONS_SCORE: 0.4287

DSS_SCORE: 0.5673

HELIX: 0.0238

FCONS_SCORE: 0.7966

RIG_SCORE: 0.6801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A251S	TCGA-A5-A0GW	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.7588
p.G246D	TCGA-CJ-5677	KIRC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1944
p.R265C	TCGA-EO-A22U	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.0556
p.Q241E	DO6718	CLLE	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.A250T	DO234199	ESAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.75
p.R264H	DO228197	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.R264H	DO41871	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.A248P	DO228985	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.25
p.P242T	DO229008	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.R263L	DO23834	LUAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1111
p.R244H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ADTTT	DEG_SPOP_SBC_1	0.1389
p.R244H	ACH-002256	Leukemia	CCLE	ADTTT	DEG_SPOP_SBC_1	0.1389
p.V241A	SIDM01045	Endometrial Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.V241A	ACH-000978	Endometrial/Uterine Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	129:133	ADTTT	SPOP	0.8638	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	292:296	ADTTT	SPOP	0.9991	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	283:287	ADTTT	SPOP	0.9945	More...
P39060	Collagen alpha-1	DEG_SPOP_SBC_1	58:62	ADTTT	SPOP	0.8165	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	246:250	ADTTT	SPOP	0.9976	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	215:219	ADTTT	SPOP	0.9952	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	38:42	ADTTT	SPOP	0.9983	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	667:671	ADTTT	SPOP	0.9939	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	251:255	ADTTT	SPOP	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons