DegronMD - O00592(PODXL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q282H	TCGA-50-5946	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2778
p.R190Q	TCGA-5C-A9VH	LIHC	TCGA	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1667
p.R190Q	TCGA-5C-A9VH	LIHC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1389
p.R190Q	TCGA-BR-8487	STAD	TCGA	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1667
p.R190Q	TCGA-BR-8487	STAD	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1389
p.P183S	TCGA-66-2756	LUSC	TCGA	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.5641
p.H208Y	TCGA-68-8250	LUSC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.2222
p.H208Y	DO219219	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.2222
p.P186T	TCGA-68-8250	LUSC	TCGA	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2778
p.S86F	TCGA-68-8250	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2222
p.T195M	TCGA-73-4668	LUAD	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation blocking phosphorylation signal	0.7222
p.T195M	TCGA-CR-7397	HNSC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation blocking phosphorylation signal	0.7222
p.D154Y	TCGA-A5-A1OF	UCEC	TCGA	PNTTS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.V53A	TCGA-AA-3811	COAD	TCGA	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation rewiring degron network	0.3056
p.T330P	TCGA-AP-A056	UCEC	TCGA	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7031
p.A80V	TCGA-AP-A1DK	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.0556
p.A80V	TCGA-EB-A3Y7	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.0556
p.R326Q	TCGA-AP-A1DV	UCEC	TCGA	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.R326Q	TCGA-AP-A1DV	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.R326Q	TCGA-AZ-4315	COAD	TCGA	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.R326Q	TCGA-AZ-4315	COAD	TCGA	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.R326Q	SIDM00178	Melanoma	GDSC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.R326Q	SIDM00178	Melanoma	GDSC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.R326Q	ACH-002386	Skin Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.R326Q	ACH-002386	Skin Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.I55T	TCGA-AP-A1DV	UCEC	TCGA	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation rewiring degron network	0.25
p.S286N	TCGA-AX-A2HG	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7069
p.E338K	TCGA-B5-A11E	UCEC	TCGA	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2222
p.A285T	TCGA-B5-A1MX	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.6028
p.T82A	TCGA-B5-A3FC	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.1111
p.P189S	TCGA-BF-A5EP	SKCM	TCGA	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1944
p.P189S	TCGA-BF-A5EP	SKCM	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1111
p.P47L	TCGA-BR-7851	STAD	TCGA	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation altering degron motif	0.6471
p.S317N	TCGA-CV-7435	HNSC	TCGA	AASTT	DEG_SPOP_SBC_1	320:324	Mutation blocking phosphorylation signal	0.6944
p.P49S	TCGA-D3-A8GB	SKCM	TCGA	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation altering degron motif	0.6752
p.P49S	DO15623	HNSC	ICGC	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation altering degron motif	0.6752
p.S291F	TCGA-D3-A8GI	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.P47S	TCGA-D6-6516	HNSC	TCGA	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation altering degron motif	0.6752
p.S316C	TCGA-D8-A73U	BRCA	TCGA	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2222
p.G84D	TCGA-DU-6392	LGG	TCGA	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.1667
p.S213L	TCGA-EE-A2MF	SKCM	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.0833
p.E121K	TCGA-EE-A3AB	SKCM	TCGA	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1111
p.N104S	TCGA-EE-A3J5	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.0556
p.A46T	TCGA-EO-A22U	UCEC	TCGA	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation rewiring degron network	0.3056
p.R275I	TCGA-EO-A22X	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.W341L	TCGA-ER-A1A1	SKCM	TCGA	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1389
p.A57T	TCGA-IB-7651	PAAD	TCGA	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation rewiring degron network	0.1944
p.K127N	TCGA-K7-A5RG	LIHC	TCGA	VATST	DEG_SPOP_SBC_1	134:138	Mutation substituting flanking lysine	0.25
p.P192L	TCGA-LN-A4A9	ESCA	TCGA	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1111
p.P192L	TCGA-LN-A4A9	ESCA	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1944
p.H206Y	TCGA-O2-A52Q	LUSC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.2778
p.I120N	TCGA-VQ-A8E3	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.T128A	DO48368	BLCA	ICGC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation blocking phosphorylation signal	0.75
p.T128A	DO48368	BLCA	ICGC	VATST	DEG_SPOP_SBC_1	134:138	Mutation blocking phosphorylation signal	0.6111
p.S89N	DO225346	BRCA	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.3056
p.Q193K	DO224942	BRCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation blocking phosphorylation signal	0.5278
p.Q193K	DO224942	BRCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation blocking phosphorylation signal	0.6667
p.Q193K	DO229041	LICA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation blocking phosphorylation signal	0.5278
p.Q193K	DO229041	LICA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation blocking phosphorylation signal	0.6667
p.H339P	DO224904	BRCA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation blocking phosphorylation signal	0.6389
p.H184Y	DO1160	BRCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.7229
p.E296D	DO1158	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.S318C	DO219629	BRCA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.0556
p.S318C	DO219629	BRCA	ICGC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.T181M	DO222574	BTCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation altering degron motif	0.7423
p.P188L	DO222952	BTCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation blocking phosphorylation signal	0.6667
p.P188L	DO222952	BTCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation blocking phosphorylation signal	0.5278
p.V55A	DO7962	COAD	ICGC	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation rewiring degron network	0.25
p.R328Q	DO8842	COAD	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7329
p.R328Q	DO43186	UCEC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7329
p.S196L	DO229010	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.3056
p.S196L	DO229016	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.3056
p.S196L	DO229003	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.3056
p.S196L	DO229005	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.3056
p.S196L	DO52365	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.3056
p.T197M	DO228123	EOPC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation altering degron motif	0.7423
p.T197M	DO50365	ESAD	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation altering degron motif	0.7423
p.T197M	DO15583	HNSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation altering degron motif	0.7423
p.T197M	DO23961	LUAD	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation altering degron motif	0.7423
p.L211F	DO11854	GBM	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation substituting flanking lysine	0.25
p.S319N	DO14918	HNSC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.0833
p.S319N	DO14918	HNSC	ICGC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.G86D	DO22237	LGG	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2222
p.A323E	DO228948	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7701
p.A338D	DO228974	LICA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2222
p.P92L	DO228972	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7582
p.T281N	DO228985	LICA	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.T326N	DO229019	LICA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.T326N	DO229019	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.A141D	DO229028	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1111
p.A141D	DO229028	LICA	ICGC	VATST	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.25
p.A141D	DO229028	LICA	ICGC	PNTTS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.H198N	DO229032	LICA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation altering degron motif	0.7423
p.P104T	DO229035	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.0556
p.T325N	DO229038	LICA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.25
p.T325N	DO229038	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.A177E	DO229041	LICA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.3056
p.S190R	DO229045	LICA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1667
p.S190R	DO229045	LICA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1389
p.K129N	DO52304	LIHC	ICGC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.6918
p.R192Q	DO52166	LIHC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1111
p.R192Q	DO52166	LIHC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1944
p.R192Q	DO47867	STAD	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1111
p.R192Q	DO47867	STAD	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1944
p.T290M	DO231527	LINC	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2778
p.Q284H	DO24556	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7582
p.P188T	DO26993	LUSC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation blocking phosphorylation signal	0.6667
p.P188T	DO26993	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation blocking phosphorylation signal	0.5278
p.H210Y	DO26993	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1667
p.S88F	DO26993	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.P185S	DO27128	LUSC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation blocking phosphorylation signal	0.75
p.E123K	DO222670	MELA	ICGC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.E123K	DO38057	SKCM	ICGC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.S293F	DO222753	MELA	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.S293F	DO50284	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.P333S	DO222868	MELA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.5641
p.L325F	DO46380	OV	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.25
p.L325F	DO46380	OV	ICGC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.A59T	DO46657	PAAD	ICGC	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation rewiring degron network	0.1389
p.A82V	DO228138	PBCA	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.1111
p.A82V	DO37499	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.1111
p.A82V	DO42033	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.1111
p.A323T	DO232761	PBCA	ICGC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7139
p.G93E	DO229459	SKCA	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7199
p.W343L	DO37413	SKCM	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation substituting flanking lysine	0.1944
p.P51S	DO50280	SKCM	ICGC	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation altering degron motif	0.6752
p.P191S	DO223906	SKCM	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.1389
p.P191S	DO223906	SKCM	ICGC	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1667
p.P49L	DO38711	STAD	ICGC	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation altering degron motif	0.7582
p.I122N	DO51759	STAD	ICGC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation blocking phosphorylation signal	0.5833
p.I57T	DO43186	UCEC	ICGC	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation rewiring degron network	0.1944
p.E340K	DO41644	UCEC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1667
p.A287T	DO41999	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.T84A	DO41871	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.1667
p.R277I	DO43907	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1389
p.D156Y	DO42568	UCEC	ICGC	PNTTS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0833
p.T169I	DO42568	UCEC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.0833
p.A48T	DO43755	UCEC	ICGC	PTPASS	DEG_SCF_FBW7_1	47:52	Mutation altering degron motif	0.7139
p.S288N	DO41337	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7069
p.T332P	DO43971	UCEC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7031
p.P328L	SIDM00545	Melanoma	GDSC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.6471
p.P328L	ACH-000987	Skin Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.6471
p.P328L	Mewo	skin	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.6471
p.E294K	SIDM00401	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.E294K	ACH-000614	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.E294K	ACH-002461	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.E294K	RVH-421	skin	COSMIC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.M314I	SIDM00185	Melanoma	GDSC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.M314I	ACH-002152	Skin Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.M314I	LB2518-MEL	skin	COSMIC	AASTT	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1667
p.Q293H	SIDM00789	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.Q293H	ACH-000997	Colon/Colorectal Cancer	CCLE	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.Q293H	ACH-001061	Colon/Colorectal Cancer	CCLE	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.Q293H	HCT-15	large intestine	COSMIC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.I120T	SIDM00607	Glioblastoma	GDSC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.I120T	SIDM00083	Glioblastoma	GDSC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.I120T	ACH-000622	Brain Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.I120T	KNS-42	central nervous system	COSMIC	ADTTT	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.P186R	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2778
p.P186R	ACH-000785	Lung Cancer	CCLE	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2778
p.P186R	NCI-H2126	lung	COSMIC	LTTPHPT	DEG_SCF_FBW7_1	178:184	Mutation rewiring degron network	0.2778
p.A336V	SIDM00511	Small Cell Lung Carcinoma	GDSC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.A336V	ACH-000257	Lung Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.A336V	COR-L279	lung	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2778
p.P90L	SIDM00214	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7582
p.P90L	SNU-407	large intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7582
p.T334A	SIDM00567	Other Solid Cancers	GDSC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7139
p.T334A	ACH-000776	Brain Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7139
p.T334A	ONS-76	central nervous system	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7139
p.S286G	SIDM01447	Glioblastoma	GDSC	PASST	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.6993
p.D154N	ACH-000543	Brain Cancer	CCLE	PNTTS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.N157S	ACH-000850	Non-Cancerous	CCLE	PNTTS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.0556
p.P328S	ACH-001067	Brain Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.6752
p.P298H	ACH-001377	Pancreatic Cancer	CCLE	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.I212M	ACH-001991	Primary	CCLE	PVATPTSS	DEG_SCF_FBW7_1	197:204	Mutation rewiring degron network	0.1111
p.M282I	LB2518-MEL	skin	COSMIC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2778
p.P296L	Mewo	skin	COSMIC	PASST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.D341E	HCC-827	lung	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PODXL

UniProt ID: O00592

Entrez ID: 5420

Protein name: Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PODXL in