DegronMD

Uniprot ID: O00592

Source protein: Podocalyxin

Source gene: PODXL

Class: DEG_SPOP_SBC_1

Location: 90:94

E3 ligase: SPOP

DEGRON score: 0.9852

ASA_SCORE: 79.4

COIL: 0.893

CONS_SCORE: 0.3636

DSS_SCORE: 0.5452

HELIX: 0.0312

FCONS_SCORE: 1.2177

RIG_SCORE: 0.6796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S86F	TCGA-68-8250	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2222
p.A80V	TCGA-AP-A1DK	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0556
p.A80V	TCGA-EB-A3Y7	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0556
p.T82A	TCGA-B5-A3FC	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1111
p.G84D	TCGA-DU-6392	LGG	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1667
p.N104S	TCGA-EE-A3J5	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0556
p.S89N	DO225346	BRCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.G86D	DO22237	LGG	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.P92L	DO228972	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7582
p.P104T	DO229035	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0556
p.S88F	DO26993	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.A82V	DO228138	PBCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.A82V	DO37499	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.A82V	DO42033	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.G93E	DO229459	SKCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7199
p.T84A	DO41871	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.P90L	SIDM00214	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.7582
p.P90L	SNU-407	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons