DegronMD

Uniprot ID: O75150

Source protein: E3 ubiquitin-protein ligase BRE1B

Source gene: RNF40

Class: DEG_SPOP_SBC_1

Location: 568:572

E3 ligase: SPOP

DEGRON score: 0.8754

ASA_SCORE: 84.68

COIL: 0.8938

CONS_SCORE: 0.2865

DSS_SCORE: 0.7005

HELIX: 0.062

FCONS_SCORE: 0.9723

RIG_SCORE: 0.6352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R561T	TCGA-IR-A3LK	CESC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1389
p.R561T	DO44299	CESC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.P566A	TCGA-ZF-A9R0	BLCA	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2778
p.P566A	DO219055	BLCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.T572A	DO233205	GACA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7139
p.E573V	ACH-000574	Ovarian Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.3056
p.E573V	FU-OV-1	ovary	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.R562L	ACH-000868	Lung Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.2778
p.S581N	ACH-000921	Lung Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons