DegronMD

Uniprot ID: Q96MZ4

Source protein: Protein FAM218A

Source gene: FAM218A

Class: DEG_SPOP_SBC_1

Location: 63:67

E3 ligase: SPOP

DEGRON score: 0.8498

ASA_SCORE: 53.86

COIL: 0.5746

CONS_SCORE: 0

DSS_SCORE: 0.3955

HELIX: 0.0366

FCONS_SCORE: 0

RIG_SCORE: 0.7456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L59F	TCGA-64-1676	LUAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2222
p.L59F	DO23629	LUAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.V69I	TCGA-D5-6924	COAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2778
p.V69I	DO7922	COAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.S77F	TCGA-FR-A726	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0556
p.S77F	DO48665	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0556
p.L74P	TCGA-XF-A9T3	BLCA	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1389
p.L74P	DO51922	BLCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.H54R	DO229010	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.H54R	DO229013	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.H54R	DO229016	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.H54R	DO229003	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.T65M	DO51493	PACA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7423
p.R53H	SIDM00839	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.0556
p.R53H	ACH-000950	Colon/Colorectal Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.0556
p.R53H	LoVo	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons