DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_SPOP_SBC_1

Location: 584:588

E3 ligase: SPOP

DEGRON score: 0.6872

ASA_SCORE: 88.28

COIL: 0.8994

CONS_SCORE: 0.5263

DSS_SCORE: 0.3078

HELIX: 0.0116

FCONS_SCORE: 1.1045

RIG_SCORE: 0.7531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S598L	TCGA-EB-A3XD	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.5
p.S598L	DO37871	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.5
p.A591V	DO224577	BRCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.25
p.L589F	DO222868	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.P590T	SIDM01943	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.T588A	SIDM00305	Ovarian Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.7139
p.T588A	JHOS-2	ovary	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.7139
p.G585S	ACH-000436	Myeloma	CCLE	PGTTT	DEG_SPOP_SBC_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons