DegronMD

Uniprot ID: P51610

Source protein: Host cell factor 1

Source gene: HCFC1

Class: DEG_SPOP_SBC_1

Location: 763:767

E3 ligase: SPOP

DEGRON score: 0.9496

ASA_SCORE: 86.3

COIL: 0.8758

CONS_SCORE: 0.4495

DSS_SCORE: 0.4889

HELIX: 0.0162

FCONS_SCORE: 0.9503

RIG_SCORE: 0.7501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T771I	TCGA-23-1121	OV	TCGA	PGTTT	DEG_SPOP_SBC_1	0.6667
p.T771I	DO28731	OV	ICGC	PGTTT	DEG_SPOP_SBC_1	0.6667
p.V756F	TCGA-61-2016	OV	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1389
p.V756F	TCGA-QH-A6CU	LGG	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1389
p.V756F	DO44532	LGG	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.V756F	DO28461	OV	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.A776V	TCGA-AA-3947	COAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0833
p.A776V	DO8192	COAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.G764S	TCGA-EY-A2OM	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.5882
p.G764S	DO43025	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.5882
p.V756I	DO52450	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.M774I	DO228912	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.S754R	DO229022	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.S755R	DO229022	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.5556
p.P763L	DO218906	SKCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7582
p.T767A	SIDM00654	Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.7139
p.T767A	ACH-000866	Lung Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.7139
p.T767A	NCI-H1048	lung	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons