DegronMD

Uniprot ID: Q13642

Source protein: Four and a half LIM domains protein 1

Source gene: FHL1

Class: DEG_SPOP_SBC_1

Location: 311:315

E3 ligase: SPOP

DEGRON score: 0.8812

ASA_SCORE: 75.42

COIL: 0.866

CONS_SCORE: 0.7565

DSS_SCORE: 0.5717

HELIX: 0.0428

FCONS_SCORE: 0.982

RIG_SCORE: 0.6644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D309V	TCGA-AP-A1DK	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2778
p.D309V	DO42033	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.A301T	TCGA-AX-A1CE	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0556
p.V303A	TCGA-BR-4363	STAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1111
p.V303A	DO38815	STAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.A322V	TCGA-D1-A17Q	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1389
p.A322V	DO41903	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.M307I	TCGA-UC-A7PG	CESC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2222
p.P323L	DO233679	GACA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.D304G	SNU-1040	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons