DegronMD - Q96MZ4(FAM218A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L59F	TCGA-64-1676	LUAD	TCGA	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2222
p.L59F	DO23629	LUAD	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2222
p.V69I	TCGA-D5-6924	COAD	TCGA	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.V69I	DO7922	COAD	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.2778
p.S77F	TCGA-FR-A726	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.S77F	DO48665	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.L74P	TCGA-XF-A9T3	BLCA	TCGA	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1389
p.L74P	DO51922	BLCA	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1389
p.H54R	DO229010	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0833
p.H54R	DO229013	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0833
p.H54R	DO229016	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0833
p.H54R	DO229003	COCA	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0833
p.T65M	DO51493	PACA	ICGC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.7423
p.R53H	SIDM00839	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.R53H	ACH-000950	Colon/Colorectal Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.R53H	LoVo	large intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons