DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 2268:2272

E3 ligase: SPOP

DEGRON score: 0.9849

ASA_SCORE: 81.74

COIL: 0.881

CONS_SCORE: 0.2844

DSS_SCORE: 0.8488

HELIX: 0.0132

FCONS_SCORE: 1.0548

RIG_SCORE: 0.4509

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2268Q	TCGA-22-4613	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.7035
p.T2262S	TCGA-37-3792	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1667
p.T2271N	TCGA-51-4081	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.7055
p.T2276S	TCGA-66-2766	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2222
p.S2258N	TCGA-DK-AA6R	BLCA	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0556
p.S2267F	TCGA-QK-A6VC	HNSC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S2261N	DO219006	BLCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.R2263K	DO222575	ESCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1944
p.S2270F	DO219056	HNSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7982
p.P2260H	DO218922	LUAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T2274N	DO26544	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.T2279S	DO27747	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.T2279S	SIDM00458	Acute Myeloid Leukemia	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.T2279S	ACH-000751	Leukemia	CCLE	PGTTT	DEG_SPOP_SBC_1	0.1389
p.T2279S	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.P2271Q	DO26468	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7035
p.T2265S	DO27192	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.25
p.G2277S	DO222532	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1944
p.T2282I	DO46792	PRAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.5
p.A2278S	SIDM01199	Hepatocellular Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2278S	ACH-000493	Liver Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2278S	SNU-423	liver	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.T2282N	SIDM00761	Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.5
p.T2282N	ACH-000752	Lung Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.5
p.T2282N	NCI-H196	lung	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.5
p.A2278G	ACH-000920	Leukemia	CCLE	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2278G	CCK-81	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PGTTT