DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 1498:1502

E3 ligase: SPOP

DEGRON score: 0.9082

ASA_SCORE: 74.78

COIL: 0.7766

CONS_SCORE: 0.173

DSS_SCORE: 0.4842

HELIX: 0.0244

FCONS_SCORE: 0.7266

RIG_SCORE: 0.6739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1490T	TCGA-86-A4JF	LUAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1111
p.C1507G	TCGA-A1-A0SO	BRCA	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1944
p.R1506Q	TCGA-A5-A0GI	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T1492M	TCGA-B5-A11X	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1667
p.T1510K	TCGA-DD-AADC	LIHC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1111
p.T1502I	TCGA-FS-A1ZF	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.7078
p.C1510G	DO2020	BRCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1111
p.R1509Q	DO48244	ESCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.R1509Q	DO41807	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.R1509L	DO228952	LICA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1389
p.G1488V	DO24596	LUAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0556
p.P1493T	DO45317	LUAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1944
p.G1492V	DO230530	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.S1499L	DO220884	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7667
p.T1505I	DO38039	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.25
p.T1495M	DO43130	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.25
p.V1493I	ACH-002287	Colon/Colorectal Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.1944
p.V1493I	NCI-H630	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons