DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3525:3529

E3 ligase: SPOP

DEGRON score: 0.9452

ASA_SCORE: 82.94

COIL: 0.9026

CONS_SCORE: 0.3543

DSS_SCORE: 0.8815

HELIX: 0.0178

FCONS_SCORE: 1.2212

RIG_SCORE: 0.4507

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3523T	TCGA-55-6985	LUAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.2778
p.T3527M	TCGA-A5-A0G2	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.7423
p.G3526V	TCGA-B5-A3FA	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.6421
p.P3525Q	TCGA-DA-A1I1	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.7035
p.G3526R	TCGA-FW-A3R5	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	0.6457
p.G3526R	SIDM00392	Melanoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.6457
p.G3526R	ACH-000810	Skin Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.6457
p.G3526R	SK-MEL-30	skin	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.6457
p.P3526T	DO25659	LUAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7031
p.P3515T	DO23624	LUAD	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0556
p.P3528S	DO222415	MELA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.6752
p.G3529R	DO37406	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7568
p.P3528Q	DO37966	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7035
p.G3538A	DO234063	THCA	ICGC	PGTTT	DEG_SPOP_SBC_1	0.0833
p.G3529V	DO52402	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7532
p.T3530M	DO41235	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.S3524F	SIDM01096	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.75
p.S3524F	ACH-000400	Colon/Colorectal Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.75
p.S3524F	SK-CO-1	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.75
p.T3533S	SIDM00194	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	SIDM00234	Other Solid Cancers	GDSC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	SIDM00533	Pancreatic Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	SIDM00173	Head and Neck Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	SIDM01588	Endometrial Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	ACH-000118	Pancreatic Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	ACH-000532	Colon/Colorectal Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	ACH-000563	Lung Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	ACH-000618	Head and Neck Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	ACH-002201	Cervical Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	EBC-1	lung	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	TC-YIK	cervix	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	SNU-61	large_intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T3533S	HuP-T3	pancreas	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.R3534T	SIDM00831	Head and Neck Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1944
p.P3530L	SIDM01229	Neuroblastoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.P3530L	BE2-M17	autonomic_ganglia	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PGTTT