DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 2825:2829

E3 ligase: SPOP

DEGRON score: 0.8413

ASA_SCORE: 82.56

COIL: 0.8746

CONS_SCORE: 0.208

DSS_SCORE: 0.8713

HELIX: 0.016

FCONS_SCORE: 0.9921

RIG_SCORE: 0.4551

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2816N	TCGA-A5-A0G2	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0833
p.E2820K	TCGA-AJ-A3EL	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.1944
p.T2827A	TCGA-B5-A11E	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	0.7139
p.R2838S	TCGA-G9-7525	PRAD	TCGA	PGTTT	DEG_SPOP_SBC_1	0.0833
p.P2825T	TCGA-HE-7128	KIRP	TCGA	PGTTT	DEG_SPOP_SBC_1	0.7031
p.P2828T	DO20796	KIRP	ICGC	PGTTT	DEG_SPOP_SBC_1	0.7031
p.P2833Q	DO231096	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2222
p.T2830A	DO41644	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.3056
p.E2823K	DO41542	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.2778
p.S2819N	DO41235	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00620	Glioblastoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00319	Melanoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00454	Rhabdomyosarcoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM01117	Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM01126	Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00087	Plasma Cell Myeloma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00690	Head and Neck Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00917	Acute Myeloid Leukemia	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00878	Breast Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00254	Neuroblastoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM00808	Burkitt's Lymphoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM01617	Endometrial Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.A2835G	SIDM01254	Burkitt's Lymphoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.1667
p.S2815I	SIDM00622	Glioblastoma	GDSC	PGTTT	DEG_SPOP_SBC_1	0.0556
p.S2815I	ACH-002224	Brain Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	0.0556
p.S2815I	D-247MG	central_nervous_system	COSMIC	PGTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	90:94	PGTTT	SPOP	0.9852	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	394:398	PGTTT	SPOP	0.9903	More...
O75150	E3 ubiquitin-protein ligase BRE1B	DEG_SPOP_SBC_1	568:572	PGTTT	SPOP	0.8754	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	584:588	PGTTT	SPOP	0.6872	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	763:767	PGTTT	SPOP	0.9496	More...
Q13642	Four and a half LIM domains protein 1	DEG_SPOP_SBC_1	311:315	PGTTT	SPOP	0.8812	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	29:33	PGTTT	SPOP	0.5329	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1498:1502	PGTTT	SPOP	0.9082	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2268:2272	PGTTT	SPOP	0.9849	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2825:2829	PGTTT	SPOP	0.8413	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3525:3529	PGTTT	SPOP	0.9452	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4082:4086	PGTTT	SPOP	0.9542	More...
Q96MZ4	Protein FAM218A	DEG_SPOP_SBC_1	63:67	PGTTT	SPOP	0.8498	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTTT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PGTTT