DegronMD - O15054(KDM6B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P470A	TCGA-33-4538	LUSC	TCGA	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.0556
p.P470A	DO26695	LUSC	ICGC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.0556
p.L732V	TCGA-66-2785	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0833
p.L732V	DO26520	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0833
p.S399T	TCGA-85-6560	LUSC	TCGA	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.S399T	TCGA-D1-A1O7	UCEC	TCGA	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.S399T	DO233259	GACA	ICGC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.S399T	DO26752	LUSC	ICGC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.S399T	DO41139	UCEC	ICGC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.S562I	TCGA-A5-A0G2	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.0556
p.S562I	TCGA-A5-A0G2	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.S562I	DO41235	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.0556
p.S562I	DO41235	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0833
p.V751I	TCGA-B5-A3FC	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation altering degron motif	0.5965
p.V751I	DO41871	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation altering degron motif	0.5965
p.S405G	TCGA-BC-A10W	LIHC	TCGA	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.1389
p.S405G	DO23002	LIHC	ICGC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.1389
p.A857T	TCGA-CG-5733	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.1111
p.A857T	DO38551	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.1111
p.A857T	SIDM00596	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.1111
p.A857T	ACH-001517	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.1111
p.A857T	HEC-1	endometrium	COSMIC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.1111
p.R446L	TCGA-D3-A2JB	SKCM	TCGA	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1389
p.R446L	DO47607	SKCM	ICGC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1389
p.S552N	TCGA-DU-6392	LGG	TCGA	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation altering degron motif	0.7069
p.S552N	TCGA-DU-6392	LGG	TCGA	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.7069
p.S552N	DO22237	LGG	ICGC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation altering degron motif	0.7069
p.S552N	DO22237	LGG	ICGC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.7069
p.D539N	TCGA-EO-A22U	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.1389
p.D539N	TCGA-EO-A22U	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0556
p.D539N	DO43755	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.1389
p.D539N	DO43755	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0556
p.S867L	TCGA-ER-A19F	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7667
p.S867L	TCGA-LD-A74U	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7667
p.S867L	DO49025	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7667
p.S867L	DO37679	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7667
p.S867L	SIDM01518	Oral Cavity Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7667
p.S867L	ACH-000771	Head and Neck Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7667
p.S1025I	TCGA-EY-A215	UCEC	TCGA	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation blocking phosphorylation signal	0.6944
p.S1025I	DO42665	UCEC	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation blocking phosphorylation signal	0.6944
p.P747A	TCGA-FD-A3SP	BLCA	TCGA	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2778
p.P747A	TCGA-FD-A3SP	BLCA	TCGA	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation rewiring degron network	0.25
p.P747A	DO594	BLCA	ICGC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2778
p.P747A	DO594	BLCA	ICGC	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation rewiring degron network	0.25
p.S388F	TCGA-FW-A3R5	SKCM	TCGA	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.1667
p.S388F	DO37406	SKCM	ICGC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.1667
p.T398S	TCGA-HU-A4G8	STAD	TCGA	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6005
p.T398S	DO47819	STAD	ICGC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6005
p.T398S	SIDM01045	Endometrial Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6005
p.T398S	ACH-000978	Endometrial/Uterine Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6005
p.S444I	TCGA-IB-7651	PAAD	TCGA	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.0833
p.S444I	DO46657	PAAD	ICGC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.0833
p.R446W	TCGA-MY-A913	CESC	TCGA	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1389
p.R446W	DO49980	CESC	ICGC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1389
p.R446W	SIDM00660	Colorectal Carcinoma	GDSC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1389
p.R446W	ACH-000985	Colon/Colorectal Cancer	CCLE	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1389
p.R446W	LS-411N	large intestine	COSMIC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1389
p.G859S	TCGA-P8-A6RX	PCPG	TCGA	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.1667
p.A750T	TCGA-PG-A917	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation altering degron motif	0.7139
p.A750T	DO52424	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation altering degron motif	0.7139
p.L1021R	TCGA-PK-A5H9	ACC	TCGA	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation altering degron motif	0.8428
p.S864C	TCGA-XF-AAN5	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.3056
p.S864C	DO51945	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.3056
p.S864F	TCGA-YC-A89H	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.3056
p.S864F	DO51948	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.3056
p.R1015C	DO222427	BTCA	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation altering degron motif	0.8301
p.T761A	DO222867	BTCA	ICGC	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation rewiring degron network	0.1389
p.T761A	DO222913	BTCA	ICGC	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation rewiring degron network	0.1389
p.D582A	DO228067	EOPC	ICGC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.1667
p.A454D	DO50387	ESAD	ICGC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation altering degron motif	0.6682
p.R1031H	DO234336	ESAD	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation rewiring degron network	0.0833
p.A741G	DO48221	ESCA	ICGC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation altering degron motif	0.754
p.A879S	DO223016	ESCA	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.0556
p.A879S	DO223039	ESCA	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.0556
p.K1006N	DO229037	LICA	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation substituting flanking lysine	0.2222
p.T551P	DO229050	LICA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation altering degron motif	0.5919
p.T551P	DO229050	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.7031
p.D739E	DO233298	NACA	ICGC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2778
p.W878R	DO35228	PACA	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation rewiring degron network	0.0833
p.A741V	DO232224	PBCA	ICGC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation altering degron motif	0.5825
p.S866F	DO218849	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.6871
p.P448L	DO37432	SKCM	ICGC	PAATPHLS	DEG_SCF_FBW7_1	453:460	Mutation rewiring degron network	0.1944
p.P742T	DO229221	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation altering degron motif	0.5919
p.V569M	SIDM01278	Colorectal Carcinoma	GDSC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2222
p.T397S	SIDM00845	Burkitt's Lymphoma	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6005
p.A386V	SIDM00454	Rhabdomyosarcoma	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.1111
p.G559A	SIDM00602	Gastric Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.1389
p.G559A	SIDM00602	Gastric Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G559A	SIDM00082	Melanoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.1389
p.G559A	SIDM00082	Melanoma	GDSC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G559A	SIDM01078	Small Cell Lung Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.1389
p.G559A	SIDM01078	Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G559A	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.1389
p.G559A	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.G559A	SIDM00665	Gastric Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.1389
p.G559A	SIDM00665	Gastric Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.1667
p.R1016Q	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation altering degron motif	0.6218
p.R1016Q	ACH-000021	Lung Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation altering degron motif	0.6218
p.R1016Q	ACH-000033	Lung Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation altering degron motif	0.6218
p.R1016Q	NCI-H1693	lung	COSMIC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation altering degron motif	0.6218
p.N407S	SIDM00860	Head and Neck Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.0833
p.E1026K	SIDM01242	Melanoma	GDSC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation rewiring degron network	0.2222
p.E1026K	ACH-002084	Skin Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation rewiring degron network	0.2222
p.E1026K	ACH-002162	Skin Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation rewiring degron network	0.2222
p.E1026K	MMAC-SF	skin	COSMIC	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation rewiring degron network	0.2222
p.P549S	SIDM00333	Endometrial Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation altering degron motif	0.6752
p.P549S	SIDM00333	Endometrial Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.6752
p.P549S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation altering degron motif	0.6752
p.P549S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation altering degron motif	0.6752
p.P747L	SIDM00333	Endometrial Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2778
p.P747L	SIDM00333	Endometrial Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation rewiring degron network	0.25
p.P747L	MFE-319	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2778
p.P747L	MFE-319	endometrium	COSMIC	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation rewiring degron network	0.25
p.S867A	SIDM00014	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7588
p.S867A	LIM1215	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7588
p.S399I	SIDM00629	Breast Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.3056
p.G395D	SIDM00217	Colorectal Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6087
p.G395D	ACH-000999	Colon/Colorectal Cancer	CCLE	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6087
p.G395D	SNU-1040	large intestine	COSMIC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation altering degron motif	0.6087
p.A578V	SIDM00217	Colorectal Carcinoma	GDSC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2778
p.A578V	ACH-000999	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2778
p.A578V	SNU-1040	large intestine	COSMIC	PPPY	ITCH	573:576	Mutation rewiring degron network	0.2778
p.S406I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation blocking phosphorylation signal	0.5556
p.A386D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PGTTT	DEG_SPOP_SBC_1	394:398	Mutation rewiring degron network	0.1111
p.S867W	SIDM01662	Plasma Cell Myeloma	GDSC	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7874
p.S867W	ACH-000564	Myeloma	CCLE	ASSSS	DEG_SPOP_SBC_1	865:869	Mutation altering degron motif	0.7874
p.G1030A	ACH-000561	Esophageal Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation rewiring degron network	0.1111
p.A763T	ACH-000969	Colon/Colorectal Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	750:754	Mutation rewiring degron network	0.0833
p.S563N	ACH-000985	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.0556
p.S563N	ACH-000985	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	573:576	Mutation rewiring degron network	0.0556
p.Q1029R	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	1014:1022	Mutation rewiring degron network	0.1389
p.N555H	ACH-001544	Esophageal Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.25
p.N555H	ACH-001544	Esophageal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	549:553	Mutation rewiring degron network	0.2778
p.P735L	ACH-002349	Non-Cancerous	CCLE	APTTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM6B

UniProt ID: O15054

Entrez ID: 23135

Protein name: Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM6B in