DegronMD

Uniprot ID: O15054

Source protein: Lysine-specific demethylase 6B

Source gene: KDM6B

Class: DEG_APCC_DBOX_1

Location: 1014:1022

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9875

ASA_SCORE: 82.8667

COIL: 0.62

CONS_SCORE: 0.6025

DSS_SCORE: 0.6214

HELIX: 0.2611

FCONS_SCORE: 1.4533

RIG_SCORE: 0.7264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1025I	TCGA-EY-A215	UCEC	TCGA	SRRVLGNLD	DEG_APCC_DBOX_1	0.6944
p.S1025I	DO42665	UCEC	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	0.6944
p.L1021R	TCGA-PK-A5H9	ACC	TCGA	SRRVLGNLD	DEG_APCC_DBOX_1	0.8428
p.R1015C	DO222427	BTCA	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	0.8301
p.R1031H	DO234336	ESAD	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	0.0833
p.K1006N	DO229037	LICA	ICGC	SRRVLGNLD	DEG_APCC_DBOX_1	0.2222
p.R1016Q	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	SRRVLGNLD	DEG_APCC_DBOX_1	0.6218
p.R1016Q	ACH-000021	Lung Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	0.6218
p.R1016Q	ACH-000033	Lung Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	0.6218
p.R1016Q	NCI-H1693	lung	COSMIC	SRRVLGNLD	DEG_APCC_DBOX_1	0.6218
p.E1026K	SIDM01242	Melanoma	GDSC	SRRVLGNLD	DEG_APCC_DBOX_1	0.2222
p.E1026K	ACH-002084	Skin Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	0.2222
p.E1026K	ACH-002162	Skin Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	0.2222
p.E1026K	MMAC-SF	skin	COSMIC	SRRVLGNLD	DEG_APCC_DBOX_1	0.2222
p.G1030A	ACH-000561	Esophageal Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	0.1111
p.Q1029R	ACH-000993	Endometrial/Uterine Cancer	CCLE	SRRVLGNLD	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_APCC_DBOX_1	1014:1022	SRRVLGNLD	APC,CDC20,FZR1	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons