DegronMD

Uniprot ID: O15054

Source protein: Lysine-specific demethylase 6B

Source gene: KDM6B

Class: DEG_SCF_FBW7_1

Location: 546:552

E3 ligase: FBXW7

DEGRON score: 0.9817

ASA_SCORE: 101.1143

COIL: 0.9744

CONS_SCORE: 0.414

DSS_SCORE: 0.8239

HELIX: 0.0123

FCONS_SCORE: 1.1085

RIG_SCORE: 0.5248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S562I	TCGA-A5-A0G2	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.0556
p.S562I	DO41235	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.0556
p.S552N	TCGA-DU-6392	LGG	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.7069
p.S552N	DO22237	LGG	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.7069
p.D539N	TCGA-EO-A22U	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.D539N	DO43755	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.T551P	DO229050	LICA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.5919
p.G559A	SIDM00602	Gastric Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.G559A	SIDM00082	Melanoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.G559A	SIDM01078	Small Cell Lung Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.G559A	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.G559A	SIDM00665	Gastric Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.P549S	SIDM00333	Endometrial Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.6752
p.P549S	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	0.6752
p.N555H	ACH-001544	Esophageal Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SCF_FBW7_1	546:552	PPTPTTS	FBXW7	0.9817	More...
O43155	Leucine-rich repeat transmembrane protein FLRT2	DEG_SCF_FBW7_1	397:403	PPTPTTS	FBXW7	0.9719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons